ArticleBiophysical journal2000
Switching from simple to complex oscillations in calcium signaling.
Article in Biophysical journal, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
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Who cites it
47 citing papers in PubMed, 184 citations in OpenAlex.
- CaFrontiers in cellular neuroscience · 2025Review
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- Calcium oscillations in HEK293 cells lacking SOCE suggest the existence of a balanced regulation of IPFrontiers in systems biology · 2024Article
- Modeling IPBiophysical journal · 2023Article
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- Deregulation of CaInternational journal of molecular sciences · 2021Article
- GPCR mediated control of calcium dynamics: A systems perspective.Cellular signalling · 2020Review
- Effect of delay in transportation of extracellular glucose into cardiomyocytes under diabetic condition: a study through mathematical model.Journal of biological physics · 2020Article
- IPiScience · 2020Article
- Differential equation-based minimal model describing metabolic oscillations inRoyal Society open science · 2020Article
- Emergence of Mixed Mode Oscillations in Random Networks of Diverse Excitable Neurons: The Role of Neighbors and Electrical Coupling.Frontiers in computational neuroscience · 2020Article
- Mechanistic inferences on metabolic dysfunction in posttraumatic stress disorder from an integrated model and multiomic analysis: role of glucocorticoid receptor sensitivity.American journal of physiology. Endocrinology and metabolism · 2019Article
- Computational Analysis of Insulin-Glucagon Signalling Network: Implications of Bistability to Metabolic Homeostasis and Disease states.Scientific reports · 2019Article
- A Neuromorphic Digital Circuit for Neuronal Information Encoding Using Astrocytic Calcium Oscillations.Frontiers in neuroscience · 2019Article
- Exploring the intrinsic behaviour of multisite phosphorylation systems as part of signalling pathways.Journal of the Royal Society, Interface · 2018Article
- Evaluation of Parallel Tempering to Accelerate Bayesian Parameter Estimation in Systems Biology.Proceedings. Euromicro International Conference on Parallel, Distributed, and Network-based Processing · 2018Article
- COPASI and its applications in biotechnology.Journal of biotechnology · 2017Review
- Article
- The Effect of Gap Junctional Coupling on the Spatiotemporal Patterns of Ca2+ Signals and the Harmonization of Ca2+-Related Cellular Responses.PLoS computational biology · 2016Article
- A G-protein subunit translocation embedded network motif underlies GPCR regulation of calcium oscillations.Biophysical journal · 2014Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present a new model for calcium oscillations based on experiments in hepatocytes. The model considers feedback inhibition on the initial agonist receptor complex by calcium and activated phospholipase C, as well as receptor type-dependent self-enhanced behavior of the activated G(alpha) subunit. It is able to show simple periodic oscillations and periodic bursting, and it is the first model to display chaotic bursting in response to agonist stimulations. Moreover, our model offers a possible explanation for the differences in dynamic behavior observed in response to different agonists in hepatocytes.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.