ArticleAmerican journal of human genetics2000
Transmission/disequilibrium tests using multiple tightly linked markers.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers, 1 of them a synthesis that pooled it.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
56 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetic endophenotypes for insomnia of major depressive disorder and treatment-induced insomnia.Journal of neural transmission (Vienna, Austria : 1996) · 2019Pooled it
- Transmission disequilibrium of polymorphic variants in the tryptophan hydroxylase-2 gene in attention-deficit/hyperactivity disorder.Molecular psychiatry · 2005Trial
- Innovative approach to identify multigenomic and environmental interactions associated with birth defects in family-based hybrid designs.Genetic epidemiology · 2021Article
- A haplotype-based framework for group-wise transmission/disequilibrium tests for rare variant association analysis.Bioinformatics (Oxford, England) · 2015Article
- Family studies of type 1 diabetes reveal additive and epistatic effects between MGAT1 and three other polymorphisms.Genes and immunity · 2014Article
- Article
- Power analysis of C-TDT for small sample size genome-wide association studies by the joint use of case-parent trios and pairs.Computational and mathematical methods in medicine · 2013Article
- A sparse transmission disequilibrium test for haplotypes based on Bradley-Terry graphs.Human heredity · 2012Article
- Pseudosibship methods in the case-parents design.Statistics in medicine · 2011Article
- Combining an evolution-guided clustering algorithm and haplotype-based LRT in family association studies.BMC genetics · 2011Article
- Genome-wide association filtering using a highly locus-specific transmission/disequilibrium test.Human genetics · 2010Article
- A data-driven weighting scheme for family-based genome-wide association studies.European journal of human genetics : EJHG · 2010Article
- Efficient calculation of P-value and power for quadratic form statistics in multilocus association testing.Annals of human genetics · 2010Article
- A variable-sized sliding-window approach for genetic association studies via principal component analysis.Annals of human genetics · 2009Article
- Evidence that TGFA influences risk to cleft lip with/without cleft palate through unconventional genetic mechanisms.Human genetics · 2009Article
- Maternal transmission effects of the PAX genes among cleft case-parent trios from four populations.European journal of human genetics : EJHG · 2009Article
- Most parsimonious haplotype allele sharing determination.BMC bioinformatics · 2009Article
- A new association test to test multiple-marker association.Genetic epidemiology · 2009Article
- Modeling Informatively Missing Genotypes in Haplotype Analysis.Communications in statistics: theory and methods · 2009Article
- Differential parental transmission of markers in BCL3 among Korean cleft case-parent trios.Journal of preventive medicine and public health = Yebang Uihakhoe chi · 2009Article
Corrections and comments
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Authors and funding
7 authors.
Funding
Abstract
Transmission/disequilibrium tests have attracted much attention in genetic studies of complex traits because (a) their power to detect genes having small to moderate effects may be greater than that of other linkage methods and (b) they are robust against population stratification. Highly polymorphic markers have become available throughout the human genome, and many such markers can be studied within short physical distances. Studies using multiple tightly linked markers are more informative than those using single markers. However, such information has not been fully utilized by existing statistical methods, resulting in possibly substantial loss of information in the identification of genes underlying complex traits. In this article, we propose novel statistical methods to analyze multiple tightly linked markers. Simulation studies comparing our methods versus existing methods suggest that our methods are more powerful. Finally, we apply the proposed methods to study genetic linkage between the dopamine D2 receptor locus and alcoholism.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.