ReviewMolecular neurobiology
Roles of transforming growth factor-alpha and related molecules in the nervous system.
Review in Molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 81 citations in OpenAlex.
- The Ambiguous Role of Growth Factors in Autism: What Do We Really Know?International journal of molecular sciences · 2025Review
- Cytokine polarized, alternatively activated bone marrow neutrophils drive axon regeneration.Nature immunology · 2024Article
- Serum Growth Factors in Schizophrenia Patients.Current issues in molecular biology · 2023Article
- Delivery Modality Affect Neonatal Levels of Inflammation, Stress, and Growth Factors.Frontiers in pediatrics · 2021Article
- TGFα preserves oligodendrocyte lineage cells and improves white matter integrity after cerebral ischemia.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2020Article
- Epidermal growth factor and its influencing variables in healthy children and adults.PloS one · 2019Article
- Correlation of Plasma EGF with Striatal Dopamine Transporter Availability in Healthy Subjects.Scientific reports · 2017Article
- M2 Phenotype Microglia-derived Cytokine Stimulates Proliferation and Neuronal Differentiation of Endogenous Stem Cells in Ischemic Brain.Experimental neurobiology · 2017Article
- Platelet-Rich Plasma Promotes Axon Regeneration, Wound Healing, and Pain Reduction: Fact or Fiction.Molecular neurobiology · 2015Review
- Decreased Phosphorylated Protein Kinase B (Akt) in Individuals with Autism Associated with High Epidermal Growth Factor Receptor (EGFR) and Low Gamma-Aminobutyric Acid (GABA).Biomarker insights · 2015Article
- Inflammatory cytokines: potential biomarkers of immunologic dysfunction in autism spectrum disorders.Mediators of inflammation · 2015Review
- Increased Epidermal Growth Factor Receptor (EGFR) Associated with Hepatocyte Growth Factor (HGF) and Symptom Severity in Children with Autism Spectrum Disorders (ASDs).Journal of central nervous system disease · 2014Article
- Transforming Growth Factor-α Improves Memory Impairment and Neurogenesis Following Ischemia Reperfusion.Cell journal · 2014Article
- Article
- Decreased Epidermal Growth Factor (EGF) Associated with HMGB1 and Increased Hyperactivity in Children with Autism.Biomarker insights · 2013Article
- Decreased levels of EGF in plasma of children with autism spectrum disorder.Autism research and treatment · 2012Article
- Increased serum levels of epidermal growth factor in children with autism.Journal of autism and developmental disorders · 2011Article
- Article
- Behavioral effects of systemic transforming growth factor-alpha in Syrian hamsters.Behavioural brain research · 2009Article
- Differentially expressed genes identified by cross-species microarray in the blind cavefish Astyanax.Integrative zoology · 2009Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The epidermal growth factor (EGF) family of polypeptides is regulators for tissue development and repair, and is characterized by the fact that their mature forms are proteolytically derived from their integral membrane precursors. This article reviews roles of the prominent members of the EGF family (EGF, transforming growth factor-alpha [TGF-alpha] and heparin-binding EGF [HB-EGF]) and the related neuregulin family in the nerve system. These polypeptides, produced by neurons and glial cells, play an important role in the development of the nervous system, stimulating proliferation, migration, and differentiation of neuronal, glial, and Schwann precursor cells. These peptides are also neurotrophic, enhancing survival and inhibiting apoptosis of post-mitotic neurons, probably acting directly through receptors on neurons, or indirectly via stimulating glial proliferation and glial synthesis of other molecules such as neurotrophic factors. TGF-alpha, EGF, and neuregulins are involved in mediating glial-neuronal and axonal-glial interactions, regulating nerve injury responses, and participating in injury-associated astrocytic gliosis, brain tumors, and other disorders of the nerve system. Although the collective roles of the EGF family (as well as those of the neuregulins) are shown to be essential for the nervous system, redundancy may exist among members of the EGF family.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.