ReviewMolecular neurobiology
Ubiquitin-mediated proteolysis in learning and memory.
Review in Molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 62 citations in OpenAlex.
- Boosting Brain Clean-Up: Can Targeting UPS Genes Offer Neuroprotection?Molecular neurobiology · 2025Review
- Molecular insights from the crabFrontiers in molecular neuroscience · 2023Review
- Article
- Proteolytic Degradation of Hippocampal STEPMolecular neurobiology · 2019Article
- A role for autophagy in long-term spatial memory formation in male rodents.Journal of neuroscience research · 2018Article
- Role of proteasome-dependent protein degradation in long-term operant memory in Aplysia.Learning & memory (Cold Spring Harbor, N.Y.) · 2017Article
- The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer's Disease and Spinal Cord Injury.Frontiers in molecular neuroscience · 2016Review
- Protein degradation by ubiquitin-proteasome system in formation and labilization of contextual conditioning memory.Learning & memory (Cold Spring Harbor, N.Y.) · 2014Article
- Persistent long-term facilitation at an identified synapse becomes labile with activation of short-term heterosynaptic plasticity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2014Article
- Protein degradation and memory formation.Brain research bulletin · 2011Review
- Control of PKA stability and signalling by the RING ligase praja2.Nature cell biology · 2011Article
- Gene networks associated with conditional fear in mice identified using a systems genetics approach.BMC systems biology · 2011Article
- Debra, a protein mediating lysosomal degradation, is required for long-term memory in Drosophila.PloS one · 2011Article
- Activation of PERK kinase in neural cells by proteasome inhibitor treatment.Journal of neurochemistry · 2010Article
- The ubiquitin-proteasome system is necessary for long-term synaptic depression in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Serotonin induces selective cleavage of the PKA RI subunit but not RII subunit in Aplysia neurons.Biochemical and biophysical research communications · 2007Article
- Involvement of protein synthesis and degradation in long-term potentiation of Schaffer collateral CA1 synapses.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Regulation of the neuronal proteasome by Zif268 (Egr1).The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Two signaling pathways regulate the expression and secretion of a neuropeptide required for long-term facilitation in Aplysia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2006Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sensitization of defensive reflexes in Aplysia is a simple behavioral paradigm for studying both short- and long-term memory. In the marine mollusk, as in other animals, memory has at least two phases: a short-term phase lasting minutes and a long-term phase lasting several days or longer. Short-term memory is produced by covalent modification of pre-existing proteins. In contrast, long-term memory needs gene induction, synthesis of new protein, and the growth of new synapses. The switch from short-term (STF) to long-term facilitation (LTF) in Aplysia sensory neurons requires not only positive regulation through gene induction, but also the specific removal of several inhibitory proteins. One important inhibitory protein is the regulatory (R) subunit of the cAMP-dependent protein kinase (PKA). Degradation of R subunits, which is essential for initiating long-term stable memory, occurs through the ubiquitin-proteasome pathway.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.