ReviewMolecular neurobiology
Cytoplasmic dynein and microtubule transport in the axon: the action connection.
Review in Molecular neurobiology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 46 citations in OpenAlex.
- Axonopathy Underlying Amyotrophic Lateral Sclerosis: Unraveling Complex Pathways and Therapeutic Insights.Neuroscience bulletin · 2024Review
- Cytoplasmic factories for axonemal dynein assembly.Journal of cell science · 2021Article
- Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models.Science translational medicine · 2020Article
- Alpha-synuclein facilitates to form short unconventional microtubules that have a unique function in the axonal transport.Scientific reports · 2017Article
- Coupled circumferential and axial tension driven by actin and myosin influences in vivo axon diameter.Scientific reports · 2017Article
- Ciliobrevins as tools for studying dynein motor function.Frontiers in cellular neuroscience · 2015Review
- Transport and diffusion of Tau protein in neurons.Cellular and molecular life sciences : CMLS · 2014Review
- Unconventional functions of microtubule motors.Archives of biochemistry and biophysics · 2012Review
- Neurodegenerative mutation in cytoplasmic dynein alters its organization and dynein-dynactin and dynein-kinesin interactions.The Journal of biological chemistry · 2010Article
- Kinesin-5 regulates the growth of the axon by acting as a brake on its microtubule array.The Journal of cell biology · 2007Article
- Kinesin-1 and Dynein are the primary motors for fast transport of mitochondria in Drosophila motor axons.Molecular biology of the cell · 2006Article
- Role of actin filaments in the axonal transport of microtubules.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
- Oligodendroglial modulation of fast axonal transport in a mouse model of hereditary spastic paraplegia.The Journal of cell biology · 2004Article
- The role of the cytoskeleton in the life cycle of viruses and intracellular bacteria: tracks, motors, and polymerization machines.Current drug targets. Infectious disorders · 2002Article
- Energetics and oxidative stress in synaptic plasticity and neurodegenerative disorders.Neuromolecular medicine · 2002Review
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The neuron uses two families of microtubule-based motors for fast axonal transport, kinesin, and cytoplasmic dynein. Cytoplasmic dynein moves membranous organelles from the distal regions of the axon to the cell body. Because dynein is synthesized in the cell body, it must first be delivered to the axon tip. It has recently been shown that cytoplasmic dynein is moved from the cell body along the axon by two different mechanisms. A small amount is associated with fast anterograde transport, the membranous organelles moved by kinesin. Most of the dynein is transported in slow component b, the actin-based transport compartment. Dynactin, a protein complex that binds dynein, is also transported in slow component b. The dynein in slow component b binds to microtubules in an ATP-dependent manner in vitro, suggesting that this dynein is enzymatically active. The finding that functionally active dynein, and dynactin, are associated with the actin-based transport compartment suggests a mechanism whereby dynein anchored to the actin cytoskeleton via dynactin provides the motive force for microtubule movement in the axon.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.