ArticleJapanese journal of cancer research : Gann2000
Preparation and characterization of antibodies against human ribosomal proteins: heterogeneous expression of S11 and S30 in a panel of human cancer cell lines.
Article in Japanese journal of cancer research : Gann, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 28 citations in OpenAlex.
- Guide snoRNAs: Drivers or Passengers in Human Disease?Biology · 2018Review
- Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma.RNA (New York, N.Y.) · 2015Article
- Regulation of alternative splicing within the supraspliceosome.Journal of structural biology · 2012Article
- Bystin in human cancer cells: intracellular localization and function in ribosome biogenesis.The Biochemical journal · 2007Article
- Ribosomal proteins and colorectal cancer.Current genomics · 2007Article
- Epigenetic activation of a subset of mRNAs by eIF4E explains its effects on cell proliferation.PloS one · 2007Article
- Fibronectin controls cap-dependent translation through beta1 integrin and eukaryotic initiation factors 4 and 2 coordinated pathways.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
- Nuclear translation: what is the evidence?RNA (New York, N.Y.) · 2003Review
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutants of model eukaryotic organisms have revealed that most ribosomal proteins are essential for cell viability. However, the precise functional role of each ribosomal protein is largely unknown. Recent reports on the involvement of ribosomal proteins in various genetic diseases and studies on the extraribosomal functions of these proteins have cast some light on their localization and functions. Here we prepared rabbit polyclonal antibodies against 26 human ribosomal proteins; each of these reagents recognized a single band in immunoblots of the purified ribosome. We used these antibodies to evaluate a panel of human cancer cell lines. Although no deficiency of ribosomal proteins was observed, the abundance of S11 and S30 varied substantially among the cell lines, but the difference did not affect the biogenesis or composition of the ribosome. Therefore, the heterogeneity may be related to extraribosomal functions of S11 and S30. The antibodies described here are powerful tools for research into the molecular mechanisms of protein translation, cell-biological and medical studies on the ribosomal proteins, and ultimately a comprehensive understanding of all ribosomal proteins (rising dbl quote, left (low)ribosomics").
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