ArticleJapanese journal of cancer research : Gann2000
Allelic loss of the region of chromosome 1p35-pter is associated with progression of human gastric carcinoma.
Article in Japanese journal of cancer research : Gann, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- GADD45A expression is correlated with patient prognosis in esophageal cancer.Oncology letters · 2016Article
- Cloning and expression analysis of the gastric carcinoma-related gene, ELCOX3.Oncology letters · 2013Article
- Article
- cDNA suppression subtraction library for screening down-regulated genes in gastric carcinoma.World journal of gastroenterology · 2003Article
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7 authors.
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Abstract
In order to identify the region on distal chromosome 1p that is thought to include one or more tumor suppressor genes for gastric carcinoma, 39 gastric carcinomas were examined for allelic loss using 11 polymorphic microsatellite markers and 1 marker of single strand conformation polymorphism. Loss of heterozygosity (LOH) was found in 18 (46%) of 39 informative patients. The regions with high frequency of loss of heterozygosity were the loci at D1S548 (6 / 17; 35.3%) and D1S2843 (7 / 20; 35%), and we found three commonly deleted regions on chromosome 1p35-pter. The frequency of allelic loss in the region of chromosome 1p35-pter was significantly associated with advanced-stage gastric carcinoma, but not with early-stage tumor or with the histology. These results suggest that allelic loss at chromosome 1p35-pter may play a role in the progression of gastric carcinoma.
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