ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2000
Defect of tyrosine hydroxylase-immunoreactive neurons in the brains of mice lacking the transcription factor Pax6.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 91 citations in OpenAlex.
- Expression atlas of Dmrt genes across sex and development in the mouse brain: functional insights from the olfactory system.Biology of sex differences · 2026Article
- Vimentin network dysregulation mediates neurite deficits inScience advances · 2025Article
- Developmental disruption and restoration of brain synaptome architecture in the murine Pax6 neurodevelopmental disease model.Nature communications · 2022Article
- Single-cell transcriptomics of human iPSC differentiation dynamics reveal a core molecular network of Parkinson's disease.Communications biology · 2022Article
- Cell-Cell Communication AlterationsFrontiers in aging neuroscience · 2022Article
- Generation of dopamine neuronal-like cells from induced neural precursors derived from adult human cells by non-viral expression of lineage factors.Journal of stem cells & regenerative medicine · 2018Article
- Embryonic development of selectively vulnerable neurons in Parkinson's disease.NPJ Parkinson's disease · 2017Review
- Regional Volume Decreases in the Brain of Pax6 Heterozygous Mutant Rats: MRI Deformation-Based Morphometry.PloS one · 2016Article
- The Shark Alar Hypothalamus: Molecular Characterization of Prosomeric Subdivisions and Evolutionary Trends.Frontiers in neuroanatomy · 2016Article
- Developmental transcription factors in age-related CNS disease: a phoenix rising from the ashes?Neural regeneration research · 2016Article
- Canonical BMP-Smad signalling promotes neurite growth in rat midbrain dopaminergic neurons.Neuromolecular medicine · 2014Article
- Conserved localization of Pax6 and Pax7 transcripts in the brain of representatives of sarcopterygian vertebrates during development supports homologous brain regionalization.Frontiers in neuroanatomy · 2014Article
- Gene expression profiling analysis of the putamen for the investigation of compensatory mechanisms in Parkinson's disease.BMC neurology · 2013Article
- Dopaminergic axon guidance: which makes what?Frontiers in cellular neuroscience · 2012Article
- A novel approach to selectively target neuronal subpopulations reveals genetic pathways that regulate tangential migration in the vertebrate hindbrain.PLoS genetics · 2011Article
- Contexts for dopamine specification by calcium spike activity in the CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Development of posterior hypothalamic neurons enlightens a switch in the prosencephalic basic plan.PloS one · 2011Article
- Article
- The evolution of dopamine systems in chordates.Frontiers in neuroanatomy · 2011Article
- Midbrain dopaminergic axons are guided longitudinally through the diencephalon by Slit/Robo signals.Molecular and cellular neurosciences · 2011Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In the CNS, the lack of the transcription factor Pax6 has been associated with early defects in cell proliferation, cell specification, and axonal pathfinding of discrete neuronal populations. In this study, we show that Pax6 is expressed in discrete catecholaminergic neuronal populations of the developing ventral thalamus, hypothalamus, and telencephalon. In mice lacking Pax6, these catecholaminergic populations develop abnormally: those in the telencephalon are reduced in cell number or absent, whereas those in the ventral thalamus and hypothalamus are greatly displaced and densely packed. Catecholaminergic neurons of the substantia nigra (SN) and the ventral tegmental area (VTA) do not express Pax6 protein. Nevertheless, mice lacking Pax6 display an altered pathfinding of SN-VTA projections: instead of following the route of the medial forebrain bundle ventrally, most of the SN-VTA projections are deflected dorsorostrally at the pretectal-dorsal thalamic transition zone and in the dorsal thalamic alar plate. Moreover, some catecholaminergic neurons are displaced dorsally to an ectopic location at the pretectal-dorsal thalamic transition zone. Interestingly, from the pretectal-dorsal thalamic to the dorsal thalamic-ventral thalamic transition zones, mice lacking Pax6 display an ectopic ventral to dorsal expansion of the chemorepellant/chemoattractive molecule, Netrin-1. This may be responsible for both the altered pathway of catecholaminergic fibers and the ectopic location of catecholaminergic neurons in this region.
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10964956PMC6772959W1842905328What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.