ArticleProceedings of the National Academy of Sciences of the United States of America2000
A role for Timeless in epithelial morphogenesis during kidney development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 43 citations in OpenAlex.
- An integrative evaluation of circadian gene TIMELESS as a pan-cancer immunological and predictive biomarker.European journal of medical research · 2023Article
- Article
- Review
- Review
- The human Tim-Tipin complex interacts directly with DNA polymerase epsilon and stimulates its synthetic activity.The Journal of biological chemistry · 2013Article
- Individual Src-family tyrosine kinases direct the degradation or protection of the clock protein Timeless via differential ubiquitylation.Cellular signalling · 2013Article
- Article
- Stimulatory and inhibitory signaling molecules that regulate renal branching morphogenesis.Pediatric nephrology (Berlin, Germany) · 2009Review
- Pygo1 and Pygo2 roles in Wnt signaling in mammalian kidney development.BMC biology · 2007Article
- Mammalian TIMELESS and Tipin are evolutionarily conserved replication fork-associated factors.Journal of molecular biology · 2007Article
- LC-MS/MS analysis of apical and basolateral plasma membranes of rat renal collecting duct cells.Molecular & cellular proteomics : MCP · 2006Article
- Getting a buzz out of the bee genome.Genome biology · 2006Article
- Coupling of human circadian and cell cycles by the timeless protein.Molecular and cellular biology · 2005Article
- Mammalian circadian biology: elucidating genome-wide levels of temporal organization.Annual review of genomics and human genetics · 2004Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
Abstract
Central to the process of epithelial organogenesis is branching morphogenesis into tubules and ducts. In the kidney, this can be modeled by a very simple system consisting of isolated ureteric bud (UB) cells, which undergo branching morphogenesis in response to soluble factors present in the conditioned medium of a metanephric mesenchyme cell line. By employing a targeted screen to identify transcription factors involved early in the morphogenetic program leading to UB branching, we identified the mammalian ortholog of Timeless (mTim) as a potential immediate early gene (IEG) important in this process. In the embryo, mTim was found to be expressed in patterns very suggestive of a role in epithelial organogenesis with high levels of expression in the developing lung, liver, and kidney, as well as neuroepithelium. In the embryonic kidney, the expression of mTim was maximal in regions of active UB branching, and a shift from the large isoform of mTim to a smaller isoform occurred as the kidney developed. Selective down-regulation of mTim resulted in profound inhibition of embryonic kidney growth and UB morphogenesis in organ culture. A direct effect on the branching UB was supported by the observation that down-regulation of mTim in the isolated UB (cultured in the absence of mesenchyme) resulted in marked inhibition of morphogenesis, suggesting a key role for Tim in the epithelial cell morphogenetic pathway leading to the formation of branching tubules.
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Registered trials
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