ArticleProceedings of the National Academy of Sciences of the United States of America2000
Scanning electrochemical microscopy of living cells: different redox activities of nonmetastatic and metastatic human breast cells.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Aptamer-Based Scanning Electrochemical Microscopy for Specific and Localized Detection of Analyte Concentration.ACS electrochemistry · 2026Article
- Transient Single Cell Hypoxia Induced by Localized Galvanostatic Oxygen Challenge.ACS measurement science au · 2025Article
- Triple-function carbon-based CaAnalytica chimica acta · 2024Article
- The effect of redox bacteria on the programmed cell death-1 cancer immunotherapy.Research in pharmaceutical sciences · 2024Article
- Temperature Effect on the Electrochemical Current Response during Scanning Electrochemical Microscopy of Living Cells.Analytical chemistry · 2023Article
- Site-selective heat boosting electrochemiluminescence for single cell imaging.Chemical science · 2023Article
- Electrochemical sensors for oral biofilm-biomaterials interface characterization: A review.Molecular oral microbiology · 2022Review
- Enhancing scanning electrochemical microscopy's potential to probe dynamic co-culture systemsThe Analyst · 2022Article
- Scanning Ion Conductance Microscopy.Chemical reviews · 2021Review
- Unveiling the contribution of the reproductive system of individual Caenorhabditis elegans on oxygen consumption by single-point scanning electrochemical microscopy measurements.Analytica chimica acta · 2021Article
- Bioelectrical understanding and engineering of cell biology.Journal of the Royal Society, Interface · 2020Article
- Glucose Microsensor with Covalently Immobilized Glucose Oxidase for Probing Bacterial Glucose Uptake by Scanning Electrochemical Microscopy.Analytical chemistry · 2020Article
- Correlating Live Cell Viability with Membrane Permeability Disruption Induced by Trivalent Chromium.ACS omega · 2019Article
- Review
- Biological imaging with scanning electrochemical microscopy.Proceedings. Mathematical, physical, and engineering sciences · 2018Review
- Recent Advances in Scanning Electrochemical Microscopy for Biological Applications.Materials (Basel, Switzerland) · 2018Review
- A high spatiotemporal study of somatic exocytosis with scanning electrochemical microscopy and nanoITIES electrodes.Chemical science · 2018Article
- Electrochemical imaging of cells and tissues.Chemical science · 2018Review
- An overview of technologies for immobilization of enzymes and surface analysis techniques for immobilized enzymes.Biotechnology, biotechnological equipment · 2015Article
- Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Electrochemical methods have been widely used to monitor physiologically important molecules in biological systems. This report describes the first application of the scanning electrochemical microscope (SECM) to probe the redox activity of individual living cells. The possibilities of measuring the rate and investigating the pathway of transmembrane charge transfer are demonstrated. By this approach, significant differences are detected in the redox responses given by nonmotile, nontransformed human breast epithelial cells, breast cells with a high level of motility (engendered by overexpression of protein kinase Calpha), and highly metastatic breast cancer cells. SECM analysis of the three cell lines reveals reproducible differences with respect to the kinetics of charge transfer by several redox mediators.
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Registered trials
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