ArticleOncogene2000
Isolation and characterization of sixteen novel p53 response genes.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- ARTS and small-molecule ARTS mimetics upregulate p53 levels by promoting the degradation of XIAP.Apoptosis : an international journal on programmed cell death · 2024Article
- Expression and prognostic value of APOBEC2 in gastric adenocarcinoma and its association with tumor-infiltrating immune cells.BMC cancer · 2024Article
- The LATS1 and LATS2 tumor suppressors: beyond the Hippo pathway.Cell death and differentiation · 2017Review
- SORBS1 suppresses tumor metastasis and improves the sensitivity of cancer to chemotherapy drug.Oncotarget · 2017Article
- The Hippo pathway, p53 and cholesterol.Cell cycle (Georgetown, Tex.) · 2016Review
- Association between KIAA1199 overexpression and tumor invasion, TNM stage, and poor prognosis in colorectal cancer.International journal of clinical and experimental pathology · 2015Article
- Lats2 is critical for the pluripotency and proper differentiation of stem cells.Cell death and differentiation · 2014Article
- Functional proteomic analysis reveals the involvement of KIAA1199 in breast cancer growth, motility and invasiveness.BMC cancer · 2014Article
- p53: guardian of ploidy.Molecular oncology · 2011Review
- Tissue proteomics of the human mammary gland: towards an abridged definition of the molecular phenotypes underlying epithelial normalcy.Molecular oncology · 2010Article
- In situ proteomic analysis of human breast cancer epithelial cells using laser capture microdissection: annotation by protein set enrichment analysis and gene ontology.Molecular & cellular proteomics : MCP · 2010Article
- TLX1/HOX11-induced hematopoietic differentiation blockade.Oncogene · 2007Article
- A positive feedback loop between the p53 and Lats2 tumor suppressors prevents tetraploidization.Genes & development · 2006Article
- Construction of a metastasis-associated gene subtracted cDNA library of human colorectal carcinoma by suppression subtraction hybridization.World journal of gastroenterology · 2004Article
- Data mining the p53 pathway in the Fugu genome: evidence for strong conservation of the apoptotic pathway.Oncogene · 2003Article
- Stress-dependent nucleolin mobilization mediated by p53-nucleolin complex formation.Molecular and cellular biology · 2002Article
- ArgBP2 and the SoHo family of adapter proteins in oncogenic diseases.Cell adhesion & migrationReview
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The EB-1 cell line is a stable transfectant of EB, a p53 null colon carcinoma cell line, with an inducible promoter controlling expression of a wild type p53 cDNA. The induced p53 is transcriptionally active and gives rise to apoptosis in these cells. Using this cellular model for presence or absence of the transcription factor p53 and transactivated genes, the Suppression Subtractive Hybridization (SSH) technique permitted the isolation of 17 mRNA candidates (GIPs-Genes induced by p53), whose expression appears to be p53-dependent. Identity has been established for nine of the 17 isolated candidates. These are HGFL/MSP, Zap-70, APOBEC2, Ponsin/SH3P12/CAP/FLAF2, CDCrel2b/H5/Pnutl2, IgG, lats 2, cytokeratin 15 and PIG-3 (quinone oxidoreductase). The latter gene is the only GIP previously demonstrated to be p53 regulated. Of the eight remaining GIPs, six correspond to Unigene clusters. One candidate, GIP #1, is significantly homologous (72% identity) to a chicken zinc finger protein, CTCF, which binds to insulator elements and thus attenuates enhancer cross-talk between physically adjacent promoters. The p53-dependent expression of GIPs was confirmed by dependence of expression upon induction of wt p53 expression in the EB-1 cellular model and by up-regulation following activation of an endogenous wt p53 by treatment with adriamycin. Oncogene (2000) 19, 3978 - 3987.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.