ArticleProceedings of the National Academy of Sciences of the United States of America2000
Differential requirement of the cytoplasmic subregions of gamma c chain in T cell development and function.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 16 citations in OpenAlex.
- SOCS3 is a suppressor of γc cytokine signaling and constrains generation of murine Foxp3European journal of immunology · 2020Article
- The common γ-chain cytokine receptor: tricks-and-treats for T cells.Cellular and molecular life sciences : CMLS · 2016Review
- Evaluation of phenoxybenzamine in the CFA model of pain following gene expression studies and connectivity mapping.Molecular pain · 2010Article
- The interaction of LCK and the CD4 co-receptor alters the dose response of T-cells to interleukin-7.Immunology letters · 2010Article
- Cell type-specific roles of Jak3 in IL-2-induced proliferative signal transduction.Biochemical and biophysical research communications · 2007Article
- Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain.Biochemical and biophysical research communications · 2006Article
- Jak3 selectively regulates Bax and Bcl-2 expression to promote T-cell development.Molecular and cellular biology · 2001Article
Corrections and comments
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Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The common cytokine receptor gamma chain (gammac), a shared component of the receptors for IL-2, IL-4, IL-7, IL-9, and IL-15, is critical for the development and function of lymphocytes. The cytoplasmic domain of gammac consists of 85 aa, in which the carboxyl-terminal 48 aa are essential for its interaction with and activation of the Janus kinase, Jak3. Evidence has been provided that Jak3-independent signals might be transmitted via the residual membrane-proximal region; however, its role in vivo remains totally unknown. In the present study, we expressed mutant forms of gammac, which lack either most of the cytoplasmic domain or only the membrane-distal Jak3-binding region, on a gammac null background. We demonstrate that, unlike gammac or Jak3 null mice, expression of the latter, but not the former mutant, restores T lymphopoiesis in vivo, accompanied by strong expression of Bcl-2. On the other hand, the in vitro functions of the restored T cells still remained impaired. These results not only reveal the hitherto unknown role of the gammac membrane-proximal region, but also suggest the differential requirement of the cytoplasmic subregions of gammac in T cell development and function.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.