Evidence map›Paper›PMID 10961958›Full record

Trial reportCirculation2000

Visualization of fibrous cap thickness and rupture in human atherosclerotic carotid plaque in vivo with high-resolution magnetic resonance imaging.

T S Hatsukami, R Ross, N L Polissar, C Yuan

Registry-linked trialAbstract readClinical TrialComparative Study
PubMed Publisher
In one paragraph

Trial report in Circulation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02114697 (Accelerated Atherosclerosis in High Risk Population Groups), which is not on this map. Cited by 175 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
175citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02114697 phase4terminatedstarted 2014, after this paper: background citation

Accelerated Atherosclerosis in High Risk Population Groups: An Assessment by Magnetic Resonance Imaging

Ran2014Enrolled9Registered outcomes1Posted comparisons0ConditionsAtherosclerosisArmsLifestyle Modification, Statin therapy
PMID 18997196PMID 15135672PMID 10865837PMID 11181465PMID 11432882PMID 11687667PMID 11773180PMID 11877368PMID 12368635PMID 12476646PMID 12490960PMID 12655579other papers from this trial
Open the trial in the graph
3 · Its place in the literature

Who cites it

175 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Guideline
  5. Trial
  6. Trial
  7. Trial
  8. Trial
  9. Molecular imaging of atherosclerotic plaque vulnerability: a narrative review.The international journal of cardiovascular imaging · 2026
    Review
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. Review

115 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

T S HatsukamiSurgical Service, VA Puget Sound Health Care System, Seattle, WA 98108, USA.
R Ross
N L Polissar
C Yuan

Funding

MRI IDENTIFICATION--HIGH RISK ATHEROSCLEROTIC PLAQUESR01HL060213 · NHLBI · UNIVERSITY OF WASHINGTON · PI YUAN, CHUN · 1998 to 2000
$201k
MRI IN VIVO DETECTION OF UNSTABLE ATHEROSCLEROTIC PLAQUER29HL056874 · NHLBI · UNIVERSITY OF WASHINGTON · PI YUAN, CHUN · 1996 to 1999
–
NHLBI NIH HHS R01-HL-60213NHLBI NIH HHS R29-HL-56874
6 · The paper itself

Abstract

backgroundThe results of studies of advanced lesions of atherosclerosis suggest that the thickness of the fibrous cap that overlies the necrotic core distinguishes the stable lesion from one that is at high risk for rupture and thromboembolic events. We have developed a high-resolution MRI technique that can identify the fine structure of the lesion, including the fibrous cap, in vivo. The aim of the present study was to determine the agreement between in vivo MRI and lesion architecture as seen on histology and gross tissue examination to identify fibrous cap thickness and rupture. METHODS AND

resultsTwenty-two subjects who were scheduled for carotid endarterectomy underwent MRI with a 3-dimensional multiple overlapping thin slab angiography protocol. The appearance of the fibrous cap was categorized as (1) an intact, thick, (2) an intact, thin, or (3) a ruptured fibrous cap on MRI, gross, and histological sections. Thirty-six sites were available for comparison between MRI and histology. There was a high level of agreement between MRI and histological findings: 89% agreement, kappa (95% CI)=0.83 (0.67 to 1. 0), weighted kappa=0.87. Spearman's correlation coefficient was 0.88 (significant to the 0.01 level).

conclusionsThese findings indicate that high-resolution MRI with a 3-dimensional multiple overlapping thin slab angiography protocol is capable of distinguishing intact, thick fibrous caps from intact thin and disrupted caps in atherosclerotic human carotid arteries in vivo. This noninvasive technique has the potential to permit studies that examine the relationship between fibrous cap changes and clinical outcome and to permit trials that evaluate therapy intended to "stabilize" the fibrous cap.

Indexed as

Endarterectomy, CarotidCarotid ArteriesCarotid Artery, CommonCarotid StenosisHumansMagnetic Resonance AngiographyMagnetic Resonance ImagingStaining and Labeling

Identifiers

PMID10961958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.