ArticleAmerican journal of human genetics2000
A unified Haseman-Elston method for testing linkage with quantitative traits.
Article in American journal of human genetics, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed.
- Genetic correlation-guided mega-analysis of DO mice provides mechanistic insight and candidate genes for age-related pathologies.PLoS genetics · 2026Article
- The Garden of Forking Paths: Reinterpreting Haseman-Elston Regression for a Genotype-by-Environment Model.Behavior genetics · 2024Article
- Estimating heritability of glycaemic response to metformin using nationwide electronic health records and population-sized pedigree.Communications medicine · 2021Article
- An efficient method to handle the 'large p, small n' problem for genomewide association studies using Haseman-Elston regression.Journal of genetics · 2016Article
- Identity-by-descent mapping for diastolic blood pressure in unrelated Mexican Americans.BMC proceedings · 2016Article
- Detection of growth-related QTL in turbot (Scophthalmus maximus).BMC genomics · 2011Article
- Linkage of atopic dermatitis to chromosomes 4q22, 3p24 and 3q21.Human genetics · 2009Article
- Haseman-Elston regression in ascertained samples: importance of dependent variable and mean correction factor selection.Human heredity · 2008Article
- Improving power in contrasting linkage-disequilibrium patterns between cases and controls.American journal of human genetics · 2007Article
- An empirical Bayes method for updating inferences in analysis of quantitative trait loci using information from related genome scans.Genetics · 2006Article
- Software for quantitative trait analysis.Human genomics · 2005Review
- A powerful and robust method for mapping quantitative trait loci in general pedigrees.American journal of human genetics · 2005Article
- Mapping quantitative trait loci in humans: achievements and limitations.The Journal of clinical investigation · 2005Review
- Bias toward the null hypothesis in model-free linkage analysis is highly dependent on the test statistic used.American journal of human genetics · 2004Article
- Mapping quantitative traits with random and with ascertained sibships.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Genome-wide linkage scan for genes affecting longitudinal trends in systolic blood pressure.BMC genetics · 2003Article
- Comparison of Haseman-Elston regression analyses using single, summary, and longitudinal measures of systolic blood pressure.BMC genetics · 2003Article
- Linkage analysis of a derived glucose phenotype in the Genetic Analysis Workshop 13 simulated data using a variety of Haseman-Elston based regression methods.BMC genetics · 2003Article
- Recent advances in human quantitative-trait-locus mapping: comparison of methods for selected sibling pairs.American journal of human genetics · 2003Article
- Recent advances in human quantitative-trait-locus mapping: comparison of methods for discordant sibling pairs.American journal of human genetics · 2003Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Haseman and Elston (H-E) method uses a simple linear regression to model the squared trait difference of sib pairs with the shared allele identical by descent (IBD) at marker locus for linkage testing. Under this setting, the squared mean-corrected trait sum is also linearly related to the IBD sharing. However, the resulting slope estimate for either model is not efficient. In this report, we propose a simple linkage test that optimally uses information from the estimates of both models. We also demonstrate that the new test is more powerful than both the traditional one and the recently revisited H-E methods.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.