ArticleJournal of muscle research and cell motility2000
The 5'-end of the porcine perinatal myosin heavy chain gene shows alternative splicing and is clustered with repeat elements.
Article in Journal of muscle research and cell motility, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Extended 2D myotube culture recapitulates postnatal fibre type plasticity.BMC cell biology · 2015Article
- Diversity in transcriptional start site selection and alternative splicing affects the 5'-UTR of mouse striated muscle myosin transcripts.Journal of muscle research and cell motility · 2006Article
- Cluster characterisation and temporal expression of porcine sarcomeric myosin heavy chain genes.Journal of muscle research and cell motility · 2003Article
- Abundant expression of myosin heavy-chain IIB RNA in a subset of human masseter muscle fibres.Archives of oral biology · 2001Article
- Maximum shortening velocity and myosin heavy-chain isoform expression in human masseter muscle fibers.Journal of dental research · 2001Article
- Molecular and quantitative characterisation of the porcine embryonic myosin heavy chain gene.Journal of muscle research and cell motility · 2001Article
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Authors and funding
6 authors.
Funding
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Abstract
The porcine perinatal myosin heavy chain (MyHC) is a major isoform in foetal skeletal muscles. We report here on its cDNA and genomic isolation, molecular characterisation and expression. Exon 2 and the first 4 bases of exon 3 of the perinatal MyHC gene. both part of the 5'-end untranslated region, showed differential splicing. About 2% of all perinatal MyHC transcripts of a 50-day-old foetus were without exon 2 and about half were without the 4 bases at the 5'-end of exon 3. Perinatal MyHC mRNA was expressed in all hind limb muscles of a 45-day-old foetus along with the slow and embryonic MyHC isoforms in the same fibres. Unlike other sarcomeric MyHCs reported to date, the porcine perinatal promoter is clustered with repeat elements (4 SINEs and 1 microsatellite) and is without a consensus TATA box at the predicted site upstream of exon 1. Nonetheless, in reporter gene transfections, its promoter was found to be highly muscle-specific. The absence of a TATA box may point to a fundamental difference in the regulatory function between the perinatal and adult MyHC isoforms.
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