ArticleDigestive diseases and sciences2000
Early increase of bone resorption in patients with liver cirrhosis secondary to viral hepatitis.
Article in Digestive diseases and sciences, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.
- Prevalent osteoporosis and fracture risk in patients with hepatic cirrhosis: a systematic review and meta-analysis.BMC gastroenterology · 2025Pooled it
- Transient osteoporosis of the hip and fatty liver disease: Case report and pathogenic hypothesis.The Journal of international medical research · 2025Article
- Bone loss in chronic liver diseases: Could healthy liver be a requirement for good bone health?World journal of gastroenterology · 2023Review
- Article
- Association between osteoporosis and hepatitis B cirrhosis: a case-control study.African health sciences · 2020Article
- Article
- Article
- Bone Diseases in Patients with Chronic Liver Disease.International journal of molecular sciences · 2019Review
- Crosssectional Assessment of Bone Mass Density in Adults with Hepatitis B Virus and Hepatitis C Virus Infection.Scientific reports · 2019Article
- Pegylated interferon α/ribavirin therapy enhances bone mineral density in children with chronic genotype 4 HCV infection.World journal of pediatrics : WJP · 2017Article
- 25-OH vitamin D level has no impact on the efficacy of antiviral therapy in naïve genotype 1 HCV-infected patients.United European gastroenterology journal · 2017Article
- Males seropositive for hepatitis B surface antigen are at risk of lower bone mineral density: the 2008-2010 Korea National Health and Nutrition Examination Surveys.Hepatology international · 2016Article
- Osteoporosis and fractures in liver disease: relevance, pathogenesis and therapeutic implications.World journal of gastroenterology · 2014Review
- Serum sclerostin in hepatitis C virus infected patients.Journal of bone metabolism · 2014Article
- Article
- Theoretical basis of a beneficial role for vitamin D in viral hepatitis.World journal of gastroenterology · 2012Review
- Proton pump inhibitors increase the incidence of bone fractures in hepatitis C patients.Digestive diseases and sciences · 2012Article
- Chronic non-cholestatic liver disease is not associated with an increased fracture rate in children.Journal of bone and mineral metabolism · 2011Article
- Procollagen type I N-terminal propeptide (PINP) is a marker for fibrogenesis in bile duct ligation-induced fibrosis in rats.Fibrogenesis & tissue repair · 2010Article
- Current understanding of osteoporosis associated with liver disease.Nature reviews. Gastroenterology & hepatology · 2009Review
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bone loss is an established complication of cholestatic liver cirrhosis, while little is known about bone mass and metabolism in noncholestatic liver cirrhosis. The aim of the present study is, therefore, to evaluate bone mass and mineral metabolism in patients with liver cirrhosis secondary to viral hepatitis. Bone mineral density measurement at lumbar and femoral levels and the evaluation of bone and mineral metabolism and gonadal function were performed in 31 patients with liver cirrhosis and 37 healthy volunteers. Lumbar and femoral bone mineral density values were significantly lower in patients than in healthy volunteers. Prevalence and severity of bone loss increased according to the severity of liver disease. All serum indices of bone and mineral metabolism and of gonadal function showed a similar behavior, but a significant increase of bone resorption was present in all Child-Pugh classes. In particular, class A patients showed normal mean bone mineral density values but increased serum levels of the telopeptide of type I collagen. Liver cirrhosis predisposes to bone loss regardless of the presence of cholestasis. The severity of metabolic osteopathy worsens as liver function does. The underlying mechanism is represented by an increased bone resorption.
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