ArticleDigestive diseases and sciences2000
In vivo selectivity of nonsteroidal antiinflammatory drugs and gastrointestinal ulcers in rats.
Article in Digestive diseases and sciences, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 38 citations in OpenAlex.
- Ketogal Safety Profile in Human Primary Colonic Epithelial Cells and in Mice.Pharmaceuticals (Basel, Switzerland) · 2021Article
- Comparison of Nociceptive Effects of Buprenorphine, Firocoxib, and Meloxicam in a Plantar Incision Model in Sprague-Dawley Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2021Article
- Ethyl cellulose nanoparticles as a platform to decrease ulcerogenic potential of piroxicam: formulation and in vitro/in vivo evaluation.International journal of nanomedicine · 2016Article
- The effects of cyclooxygenase inhibitors on the gastric emptying and small intestine transit in the male rats following traumatic brain injury.Iranian journal of basic medical sciences · 2014Article
- Adverse effects of incorporating ketoprofen into established rodent studies.Journal of the American Association for Laboratory Animal Science : JAALAS · 2008Article
- Effect of different cyclooxygenase inhibitors on gastric adaptive cytoprotection induced by 20% ethanol.Digestive diseases and sciences · 2007Article
- Anti-tumor effect of non-steroidal anti-inflammatory drugs on human ovarian cancers.Pathology oncology research : POR · 2007Article
- Anti-inflammatory effect of bioflora probiotic administered orally or subcutaneously with live or dead bacteria.Digestive diseases and sciences · 2006Article
- Comparative study of anti-inflammatory and ulcerogenic activities of different cyclo-oxygenase inhibitors.Inflammopharmacology · 2005Article
- A pharmacokinetic comparison of meloxicam and ketoprofen following oral administration to healthy dogs.Veterinary research communications · 2004Article
- Mechanisms of NSAID-induced hepatotoxicity: focus on nimesulide.Drug safety · 2002Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of the present work was to study in vivo COX-2-COX-1 selectivity of 16 nonsteroidal anti-inflammatory drugs (NSAIDs) in equipotent ulcerogenic doses in two in vivo experimental models. Indomethacin, ibuprofen, nimesulide, aceclofenac, aspirin, sodium diclofenac, meloxicam, naproxene, paracetamol, piroxicam, tenoxicam, nabumetone, ketoprofen, mefenamic acid, etodolac, and ketorolac were administered to female Wistar rats (N = 10 each group). In experiment I, solid food plus subcutaneous NSAIDs were given. In experiment II, NSAIDs were given by oral gavage and in bolus. Macroscopic gastric antral ulcer area (30%) and intestinal erosiva area (295 mm2) in experiment I and necrotic gastric fundus area (65%) and erosive intestinal area (182 mm2), "in vivo" the NSAIDs COX-1 was showed. Neutrofilia assessed in gastric intestinal mucosa where also ibuprofen and paracetamol not given neotrophilic infiltration. In conclusion, COX-2-COX-1 selectivity was demonstrated in vivo with the drugs aceclofenac, nabumetone, meloxicam, nimesulide, and paracetamol.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.