Evidence map›Paper›PMID 10959723›Full record

ReviewInternational journal of medical microbiology : IJMM2000

Fimbriae-assisted bacterial surface display of heterologous peptides.

P Klemm, M A Schembri

Abstract readReview
In one paragraph

Review in International journal of medical microbiology : IJMM, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Review
  5. Article
  6. Expansion of a TelomericFrontiers in genetics · 2018
    Article
  7. The autodisplay story, from discovery to biotechnical and biomedical applications.Microbiology and molecular biology reviews : MMBR · 2007
    Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

P KlemmDepartment of Microbiology, Technical University of Denmark, Lyngby. impk@pop.dtu.dk
M A Schembri

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The display of peptide segments on the surface of bacteria offers many new and exciting applications in biotechnology and medical research. Fimbria-assisted display of heterologous sequences is a paradigm for chimeric organelle display on bacteria. Fimbriae are particularly attractive candidates for epitope display for several reasons: (1) they are present in extremely high numbers at the cell surface, (2) they are strong immunogens, (3) they possess inherent adhesive properties, and (4) they can be easily purified. The majority of work dealing with fimbria-assisted peptide display has been focused on the development of recombinant vaccines. A number of different fimbrial types have been used to display immune-relevant sectors of various foreign proteins. Chimeric fimbrial vaccines can be used in the context of purified proteins, however the potential also exists to exploit this technology for the development of live recombinant vaccines. Work has also been performed demonstrating the amenability of fimbriae towards the powerful technology of random peptide display. This review summarises the current state of research in this field.

Indexed as

Adhesins, Escherichia coliAntigens, BacterialEscherichia coli ProteinsFimbriae ProteinsAdhesins, BacterialAnimalsAntigens, SurfaceBacterial ProteinsCapsidEpitopesFimbriae, BacterialGram-Negative BacteriaHumansMembrane ProteinsPeptidesRecombinant Fusion ProteinsAdhesins, BacterialAdhesins, Escherichia coliAntigens, BacterialAntigens, SurfaceBacterial ProteinsclpG protein, E coliEpitopesEscherichia coli ProteinsFimbriae ProteinsfimbrillinfimH protein, E coliK88 antigen, E coliMembrane ProteinsPeptidesRecombinant Fusion ProteinsVaccines, Synthetic

Identifiers

PMID10959723
PMCPMC7129006

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.