ArticleCell proliferation2000
Sodium butyrate modulates cell cycle-related proteins in HT29 human colonic adenocarcinoma cells.
Article in Cell proliferation, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
20 citing papers in PubMed, 75 citations in OpenAlex.
- A Narrative Review: Immunometabolic Interactions of Host-Gut Microbiota and Botanical Active Ingredients in Gastrointestinal Cancers.International journal of molecular sciences · 2024Review
- Mucosal Microbiome in Patients with Early Bowel Polyps: Inferences from Short-Read and Long-Read 16S rRNA Sequencing.Cancers · 2023Article
- Article
- Dietary supplements for intestinal inflammation.Journal of preventive medicine and hygiene · 2022Review
- Effect of Sodium Butyrate on p16INK4a, p14ARF, p15INK4b, Class I HDACs (HDACs 1, 2, 3) Class II HDACs (HDACs 4, 5, 6), Cell Growth Inhibition and Apoptosis Induction in Pancreatic Cancer AsPC-1 and Colon Cancer HCT-116 Cell Lines.Asian Pacific journal of cancer prevention : APJCP · 2022Article
- Sodium Butyrate Selectively Kills Cancer Cells and Inhibits Migration in Colorectal Cancer by Targeting Thioredoxin-1.OncoTargets and therapy · 2020Article
- Exacerbation of Chikungunya Virus Rheumatic Immunopathology by a High Fiber Diet and Butyrate.Frontiers in immunology · 2019Article
- Butyrate enhances mitochondrial function during oxidative stress in cell lines from boys with autism.Translational psychiatry · 2018Article
- Review: The potential of the common bean (Phaseolus vulgaris) as a vehicle for iron biofortification.Nutrients · 2015Review
- Association between low colonic short-chain fatty acids and high bile acids in high colon cancer risk populations.Nutrition and cancer · 2012Article
- Milk fermented by Propionibacterium freudenreichii induces apoptosis of HGT-1 human gastric cancer cells.PloS one · 2012Article
- Article
- Butyrate regulates leptin expression through different signaling pathways in adipocytes.Journal of veterinary science · 2011Article
- Dietary fiber enhances TGF-β signaling and growth inhibition in the gut.American journal of physiology. Gastrointestinal and liver physiology · 2011Article
- A new oral formulation for the release of sodium butyrate in the ileo-cecal region and colon.World journal of gastroenterology · 2007Article
- A novel retinoic/butyric hyaluronan ester for the treatment of acute promyelocytic leukemia: preliminary preclinical results.Leukemia · 2006Article
- Augmentation of sodium butyrate-induced apoptosis by phosphatidylinositol 3-kinase inhibition in the human cervical cancer cell-line.Cancer research and treatment · 2006Article
- Hyaluronic-acid butyric esters as promising antineoplastic agents in human lung carcinoma: a preclinical study.Investigational new drugs · 2004Article
- In vitro effects of cholesteryl butyrate solid lipid nanospheres as a butyric acid pro-drug on melanoma cells: evaluation of antiproliferative activity and apoptosis induction.Clinical & experimental metastasis · 2000Article
- The zinc sensing receptor, a link between zinc and cell signaling.Molecular medicine (Cambridge, Mass.)Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sodium butyrate (NaB), a product of colonic fermentation of dietary fibre, has been shown to inhibit cell proliferation by blocking cells in the G0/G1 phase of the cell cycle through a mechanism of action still not completely understood. We investigated the effect of NaB on the level of some G1 phase-related proteins in a colon carcinoma cell line (HT29). In particular, we addressed our attention to cyclin D1 (the key regulator of G1S progression), p21waf1/cip1 (the main inactivator of the cyclin D/cdk complex), and p53 (the most important regulator of p21waf1/cip1 gene transcription). At inhibitory concentrations (higher than 1 mM) NaB reduced cyclin D1 and p53 level in a dose-dependent manner and sustained the synthesis of p21waf1/cip1, probably in a p53-independent way, accounting for the G0/G1 block observed by flow cytometry. Present results provide further evidence on the molecular mechanism at the basis of the physiological role of NaB and support the hypothesis that an unbalanced diet, poor in carbohydrates and therefore in NaB, could result in functional alterations with clinical and carcinogenic implications.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.