ArticleMolecular and cellular biology2000
MyoD-dependent induction during myoblast differentiation of p204, a protein also inducible by interferon.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 69 citations in OpenAlex.
- IFI204 in microglia mediates traumatic brain injury-induced mitochondrial dysfunction and pyroptosis via SENP7 interaction.Cell biology and toxicology · 2025Article
- Transfected plasmid DNA is incorporated into the nucleus via nuclear envelope reformation at telophase.Communications biology · 2022Article
- Multiple cytosolic DNA sensors bind plasmid DNA after transfection.Nucleic acids research · 2019Article
- RNA-Seq analysis of interferon inducible p204-mediated network in anti-tumor immunity.Scientific reports · 2018Article
- p204 Is Required for Canonical Lipopolysaccharide-induced TLR4 Signaling in Mice.EBioMedicine · 2018Article
- Induction of Osmolyte Pathways in Skeletal Muscle Inflammation: Novel Biomarkers for Myositis.Frontiers in neurology · 2018Article
- The PYHIN Protein p205 Regulates the Inflammasome by Controlling Asc Expression.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Regulatory roles of interferon-inducible protein 204 on differentiation and vasculogenic activity of endothelial progenitor cells.Stem cell research & therapy · 2016Article
- Comparative transcriptome analysis of muscular dystrophy models Large(myd), Dmd(mdx)/Large(myd) and Dmd(mdx): what makes them different?European journal of human genetics : EJHG · 2016Article
- The roles of interferon-inducible p200 family members IFI16 and p204 in innate immune responses, cell differentiation and proliferation.Genes & diseases · 2015Article
- Wanderings in biochemistry.The Journal of biological chemistry · 2014Article
- Interferon-inducible Ifi200-family genes as modifiers of lupus susceptibility.Immunology letters · 2012Review
- The mammalian PYHIN gene family: phylogeny, evolution and expression.BMC evolutionary biology · 2012Article
- Acetylation modulates cellular distribution and DNA sensing ability of interferon-inducible protein IFI16.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- GEP constitutes a negative feedback loop with MyoD and acts as a novel mediator in controlling skeletal muscle differentiation.Cellular and molecular life sciences : CMLS · 2012Article
- The p200 family protein p204 as a modulator of cell proliferation and differentiation: a brief survey.Cellular and molecular life sciences : CMLS · 2010Review
- p204 protein overcomes the inhibition of core binding factor alpha-1-mediated osteogenic differentiation by Id helix-loop-helix proteins.Molecular biology of the cell · 2008Article
- ADAMTS-7: a metalloproteinase that directly binds to and degrades cartilage oligomeric matrix protein.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2006Article
- Cytoskeletal protein 4.1G binds to the third intracellular loop of the A1 adenosine receptor and inhibits receptor action.The Biochemical journal · 2004Article
- Resolution of skeletal muscle inflammation in mdx dystrophic mouse is accompanied by increased immunoglobulin and interferon-gamma production.International journal of experimental pathology · 2002Article
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
Abstract
p204, an interferon-inducible p200 family protein, inhibits rRNA synthesis in fibroblasts by blocking the binding of the upstream binding factor transcription factor to DNA. Here we report that among 10 adult mouse tissues tested, the level of p204 was highest in heart and skeletal muscles. In cultured C2C12 skeletal muscle myoblasts, p204 was nucleoplasmic and its level was low. During myoblast fusion this level strongly increased, p204 became phosphorylated, and the bulk of p204 appeared in the cytoplasm of the myotubes. Leptomycin B, an inhibitor of nuclear export that blocked myoblast fusion, inhibited the nuclear export signal-dependent translocation of p204 to the cytoplasm. The increase in the p204 level during myoblast fusion was a consequence of MyoD transcription factor binding to several MyoD-specific sequences in the gene encoding p204, followed by transcription. Overexpression of p204 (in C2C12 myoblasts carrying an inducible p204 expression plasmid) accelerated the fusion of myoblasts to myotubes in differentiation medium and induced the fusion even in growth medium. The level of p204 in mouse heart muscle strongly increased during differentiation; it was barely detectable in 10. 5-day-old embryos, reached the peak level in 16.5-day-old embryos, and remained high thereafter. p204 is the second p200 family protein (after p202a) found to be involved in muscle differentiation. (p202a was formerly designated p202. The new designation is due to the identification of a highly similar protein-p202b [H. Wang, G. Chatterjee, J. J. Meyer, C. J. Liu, N. A. Manjunath, P. Bray-Ward, and P. Lengyel, Genomics 60:281-294, 1999].) These results reveal that p204 and p202a function in both muscle differentiation and interferon action.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.