ArticleMolecular and cellular biology2000
Conservation of heterochromatin protein 1 function.
Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
59 citing papers in PubMed, 127 citations in OpenAlex.
- Heterochromatin protein 1 (HP1) dysfunction drives male-biased sex ratio in Trichogramma dendrolimi (Hymenoptera: Trichogrammatidae) via paternal genome elimination during mitosis.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2026Article
- HP1 loses its chromatin clustering and phase separation function across evolution.Nature communications · 2025Article
- Phase-separated chromatin compartments: Orchestrating gene expression through condensation.Cell insight · 2024Review
- SETD4 Confers Cancer Stem Cell Chemoresistance in Nonsmall Cell Lung Cancer Patients via the Epigenetic Regulation of Cellular Quiescence.Stem cells international · 2023Article
- A complex interplay between H2A.Z and HP1 isoforms regulates pericentric heterochromatin.Frontiers in cell and developmental biology · 2023Article
- Review
- Article
- Role of HP1β during spermatogenesis and DNA replication.Chromosoma · 2020Article
- Biology and Physics of Heterochromatin-Cells · 2020Review
- Insights into HP1a-Chromatin Interactions.Cells · 2020Review
- How HP1 Post-Translational Modifications Regulate Heterochromatin Formation and Maintenance.Cells · 2020Review
- On the relations of phase separation and Hi-C maps to epigenetics.Royal Society open science · 2020Article
- On top of biosynthetic gene clusters: How epigenetic machinery influences secondary metabolism in fungi.Biotechnology advances · 2019Review
- Biophysical Properties of HP1-Mediated Heterochromatin.Cold Spring Harbor symposia on quantitative biology · 2019Article
- The Role of Phase Separation in Heterochromatin Formation, Function, and Regulation.Biochemistry · 2018Review
- Heterochromatin and the molecular mechanisms of 'parent-of-origin' effects in animals.Journal of biosciences · 2016Review
- The composition and organization of Drosophila heterochromatin are heterogeneous and dynamic.eLife · 2016Article
- Swi1Timeless Prevents Repeat Instability at Fission Yeast Telomeres.PLoS genetics · 2016Article
- HP1 knockdown is associated with abnormal condensation of almost all chromatin types in a grasshopper (Eyprepocnemis plorans).Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2014Article
- Mechanisms of functional promiscuity by HP1 proteins.Trends in cell biology · 2014Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heterochromatin represents a cytologically visible state of heritable gene repression. In the yeast, Schizosaccharomyces pombe, the swi6 gene encodes a heterochromatin protein 1 (HP1)-like chromodomain protein that localizes to heterochromatin domains, including the centromeres, telomeres, and the donor mating-type loci, and is involved in silencing at these loci. We identify here the functional domains of swi6p and demonstrate that the chromodomain from a mammalian HP1-like protein, M31, can functionally replace that of swi6p, showing that chromodomain function is conserved from yeasts to humans. Site-directed mutagenesis, based on a modeled three-dimensional structure of the swi6p chromodomain, shows that the hydrophobic amino acids which lie in the core of the structure are critical for biological function. Gel filtration, gel overlay experiments, and mass spectroscopy show that HP1 proteins can self-associate, and we suggest that it is as oligomers that HP1 proteins are incorporated into heterochromatin complexes that silence gene activity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.