Evidence map›Paper›PMID 10958689›Full record

ArticleMolecular and cellular biology2000

takeout, a novel Drosophila gene under circadian clock transcriptional regulation.

W V So, L Sarov-Blat, C K Kotarski, M J McDonald, R Allada, M Rosbash

Abstract read
In one paragraph

Article in Molecular and cellular biology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 58 papers.

0numbers the graph read from it
0cells of the map it votes in
58citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

58 citing papers in PubMed.

  1. Article
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  3. Alternative splicing ofProceedings of the National Academy of Sciences of the United States of America · 2024
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  4. Day-night gene expression reveals circadian geneProceedings. Biological sciences · 2024
    Article
  5. Alternative splicing ofbioRxiv : the preprint server for biology · 2024
    Article
  6. Article
  7. Royal Society open science · 2023
    Article
  8. Effects of Fructose and Palmitic Acid on Gene Expression inInternational journal of molecular sciences · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

W V SoHoward Hughes Medical Institute, NSF Center for Biological Timing, Department of Biology, Brandeis University, Waltham, Massachusetts 02454, USA.
L Sarov-Blat
C K Kotarski
M J McDonald
R Allada
M Rosbash

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We report the identification and characterization of a new Drosophila clock-regulated gene, takeout (to). to is a member of a novel gene family and is implicated in circadian control of feeding behavior. Its gene expression is down-regulated in all of the clock mutants tested. In wild-type flies, to mRNA exhibits daily cycling expression but with a novel phase, delayed relative to those of the better-characterized clock mRNAs, period and timeless. The E-box-containing sequence in the to promoter shows impressive similarities with those of period and timeless. However, our results suggest that the E box is not involved in the amplitude and phase of the transcriptional cycling of to. The circadian delayed transcriptional phase is therefore most likely the result of indirect regulation through unknown transcription factors.

Indexed as

Down-RegulationDrosophila ProteinsGenes, InsectAmino Acid SequenceAnimalsBase SequenceBiological ClocksCell LineCircadian RhythmDNA, ComplementaryDrosophila melanogasterHeadInsect ProteinsMolecular Sequence DataNuclear ProteinsPeriod Circadian ProteinsDNA, ComplementaryDrosophila ProteinsInsect ProteinsNuclear ProteinsPeriod Circadian ProteinsPER protein, DrosophilaRNA, Messengertim protein, DrosophilaTO protein, Drosophila

Identifiers

PMID10958689
PMCPMC88769

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.