ArticleGenome research2000
Genome-wide detection of allelic imbalance using human SNPs and high-density DNA arrays.
Article in Genome research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 54 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
54 citing papers in PubMed, 211 citations in OpenAlex.
- Combined SNP parental haplotyping and intensity analysis identifies meiotic and mitotic aneuploidies and frequent segmental aneuploidies in preimplantation human embryos.Scientific reports · 2025Article
- Identification of neoantigens for individualized therapeutic cancer vaccines.Nature reviews. Drug discovery · 2022Review
- Allelic imbalance and haploinsufficiency in MYBPC3-linked hypertrophic cardiomyopathy.Pflugers Archiv : European journal of physiology · 2019Review
- Statistical Contributions to Bioinformatics: Design, Modeling, Structure Learning, and Integration.Statistical modelling · 2017Article
- Allele-specific imbalance mapping at human orthologs of mouse susceptibility to colon cancer (Scc) loci.International journal of cancer · 2015Article
- Emerging technologies in paediatric leukaemia.Translational pediatrics · 2015Review
- Deconvolving tumor purity and ploidy by integrating copy number alterations and loss of heterozygosity.Bioinformatics (Oxford, England) · 2014Article
- Distinguishing immunorelated haemocytopenia from idiopathic cytopenia of undetermined significance (ICUS): a bone marrow abnormality mediated by autoantibodies.Clinical and experimental immunology · 2014Article
- Article
- Characterization of genetic lesions in rhabdomyosarcoma using a high-density single nucleotide polymorphism array.Cancer science · 2013Article
- Power and stability properties of resampling-based multiple testing procedures with applications to gene oncology studies.Computational and mathematical methods in medicine · 2013Article
- Absolute quantification of somatic DNA alterations in human cancer.Nature biotechnology · 2012Article
- CGH and SNP array using DNA extracted from fixed cytogenetic preparations and long-term refrigerated bone marrow specimens.Molecular cytogenetics · 2012Article
- Molecular analysis of cyst fluid aspiration in the diagnosis and risk assessment of cystic lesions of the pancreas.Clinical and translational science · 2012Review
- Article
- Array Comparative Genomic Hybridizations: assessing the ability to recapture evolutionary relationships using an in silico approach.BMC genomics · 2011Article
- Sputum-based molecular biomarkers for the early detection of lung cancer: limitations and promise.Cancers · 2011Article
- Making sense of cancer genomic data.Genes & development · 2011Review
- A pipeline for copy number variation detection based on principal component analysis.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2011Article
- Genetic aberrations in childhood acute lymphoblastic leukaemia: application of high-density single nucleotide polymorphism array.The Malaysian journal of medical sciences : MJMS · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 3 countries.
Funding
Abstract
Most human cancers are characterized by genomic instability, the accumulation of multiple genetic alterations and allelic imbalance throughout the genome. Loss of heterozygosity (LOH) is a common form of allelic imbalance and the detection of LOH has been used to identify genomic regions that harbor tumor suppressor genes and to characterize tumor stages and progression. Here we describe the use of high-density oligonucleotide arrays for genome-wide scans for LOH and allelic imbalance in human tumors. The arrays contain redundant sets of probes for 600 genetic loci that are distributed across all human chromosomes. The arrays were used to detect allelic imbalance in two types of human tumors, and a subset of the results was confirmed using conventional gel-based methods. We also tested the ability to study heterogeneous cell populations and found that allelic imbalance can be detected in the presence of a substantial background of normal cells. The detection of LOH and other chromosomal changes using large numbers of single nucleotide polymorphism (SNP) markers should enable identification of patterns of allelic imbalance with potential prognostic and diagnostic utility.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.