ArticleGenome research2000
Gene survey of the pathogenic protozoan Trypanosoma cruzi.
Article in Genome research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 45 citations in OpenAlex.
- The Draft Genome ofFrontiers in genetics · 2021Article
- Trypanosomatid comparative genomics: Contributions to the study of parasite biology and different parasitic diseases.Genetics and molecular biology · 2012Article
- Article
- Trypanosoma cruzi GP63 proteins undergo stage-specific differential posttranslational modification and are important for host cell infection.Infection and immunity · 2009Article
- Distinct profiles of expressed sequence tags during intestinal regeneration in the sea cucumber Holothuria glaberrima.Physiological genomics · 2007Article
- Evolution of tubulin gene arrays in Trypanosomatid parasites: genomic restructuring in Leishmania.BMC genomics · 2006Article
- TcruziDB: an integrated, post-genomics community resource for Trypanosoma cruzi.Nucleic acids research · 2006Article
- Trypanosoma rangeli Transcriptome Project: Generation and analysis of expressed sequence tags.Kinetoplastid biology and disease · 2004Article
- Towards a framework for the evolutionary genomics of Kinetoplastids: what kind of data and how much?Kinetoplastid biology and disease · 2003Article
- Trypanosoma cruzi expresses a plant-like ascorbate-dependent hemoperoxidase localized to the endoplasmic reticulum.Proceedings of the National Academy of Sciences of the United States of America · 2002Article
- Annotated expressed sequence tags and cDNA microarrays for studies of brain and behavior in the honey bee.Genome research · 2002Article
- A random sequencing approach for the analysis of the Trypanosoma cruzi genome: general structure, large gene and repetitive DNA families, and gene discovery.Genome research · 2000Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have performed a survey of the active genes in the important human pathogen Trypanosoma cruzi by analyzing 5013 expressed sequence tags (ESTs) generated from a normalized epimastigote cDNA library. Clustering of all sequences resulted in 771 clusters, comprising 54% of the ESTs. In total, the ESTs corresponded to 3054 transcripts that might represent one-fourth of the total gene repertoire in T. cruzi. About 33% of the T. cruzi transcripts showed similarity to sequences in the public databases, and a large number of hitherto undiscovered genes predicted to be involved in transcription, cell cycle control, cell division, signal transduction, secretion, and metabolism were identified. More than 140 full-length gene sequences were derived from the ESTs. Comparisons with all open reading frames in yeast and in Caenorhabditis elegans showed that only 12% of the T. cruzi transcripts were shared among diverse eukaryotic organisms. Comparison with other kinetoplastid sequences identified 237 orthologous genes that are shared between these evolutionarily divergent organisms. The generated data are a useful resource for further studies of the biology of the parasite and for development of new means to combat Chagas' disease.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.