ArticleGenome research2000
Genomic sequence analysis of the mouse Naip gene array.
Article in Genome research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed, 63 citations in OpenAlex.
- The gasdermin family: from pyroptosis mechanisms to therapeutic targets.Signal transduction and targeted therapy · 2026Review
- Molecular mechanisms and regulation of inflammasome activation and signaling: sensing of pathogens and damage molecular patterns.Cellular & molecular immunology · 2025Review
- NLRC4, inflammation and colorectal cancer (Review).International journal of oncology · 2024Review
- The gasdermin family: emerging therapeutic targets in diseases.Signal transduction and targeted therapy · 2024Review
- Human and mouse NAIP/NLRC4 inflammasome responses to bacterial infection.Current opinion in microbiology · 2023Review
- Pyroptosis-Induced Inflammation and Tissue Damage.Journal of molecular biology · 2022Review
- Inflammasome Contribution to the Activation of Th1, Th2, and Th17 Immune Responses.Frontiers in microbiology · 2022Review
- Advances in Understanding Activation and Function of the NLRC4 Inflammasome.International journal of molecular sciences · 2021Review
- Updating the NLRC4 Inflammasome: from Bacterial Infections to Autoimmunity and Cancer.Frontiers in immunology · 2021Review
- Inflammasomes: Their Role in Normal and Complicated Pregnancies.Journal of immunology (Baltimore, Md. : 1950) · 2019Review
- Inhibitor of apoptosis proteins in human health and disease.Genes and immunity · 2019Review
- Inflammasomes in Colitis and Colorectal Cancer: Mechanism of Action and Therapies.The Yale journal of biology and medicine · 2019Review
- Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action.Microbiology and molecular biology reviews : MMBR · 2018Review
- Emerging Roles of Inflammasomes in Acute Pneumonia.American journal of respiratory and critical care medicine · 2018Review
- Broad detection of bacterial type III secretion system and flagellin proteins by the human NAIP/NLRC4 inflammasome.Proceedings of the National Academy of Sciences of the United States of America · 2017Article
- Inflammasome activation and assembly at a glance.Journal of cell science · 2017Review
- A Mechanistic Understanding of Pyroptosis: The Fiery Death Triggered by Invasive Infection.Advances in immunology · 2017Review
- The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation.The Journal of cell biology · 2016Review
- Regulation of inflammasome activation.Immunological reviews · 2015Review
- Epithelial NAIPs protect against colonic tumorigenesis.The Journal of experimental medicine · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A mouse locus called Lgn1 determines differences in macrophage permissiveness for the intracellular replication of Legionella pneumophila. The only regional candidate genes for this phenotype difference lie within a cluster of closely linked paralogs of the Neuronal Apoptosis Inhibitory Protein (Naip) gene. Previous genetic and physical mapping of the Lgn1 phenotype narrowed it to an interval containing only Naip2 and Naip5, suggesting that there is not complete functional overlap among the mouse Naip loci. In order to gather more information about polymorphisms among the Naip genes of the 129 mouse haplotype, we have determined the genomic sequence of a substantial portion of the 129 Naip gene array. We have constructed an evolutionary model for the expansion of the Naip gene array from a single progenitor Naip gene. This model predicts the presence of two distinct families of Naip paralogs: Naip1/2/3 and Naip4/5/6/7. Unlike the divergences among all the other Naip paralogs, the splits among Naip4, Naip5, Naip6, and Naip7 occurred relatively recently. The high degree of sequence conservation within the Naip4/5/6/7 family increases the likelihood of functional overlap among these genes.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.