ReviewCurrent gastroenterology reports2000
Recent developments in chest pain of undetermined origin.
Review in Current gastroenterology reports, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00462241 (Non-cardiac Chest Pain Evaluation and Treatment Study), which is not on this map. Cited by 10 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Non-cardiac Chest Pain Evaluation and Treatment Study (CARPA) - Part 2: Treatment Study
Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Diagnostic indicators of non-cardiovascular chest pain: a systematic review and meta-analysis.BMC medicine · 2013Pooled it
- Diagnosis and treatment of musculoskeletal chest pain: design of a multi-purpose trial.BMC musculoskeletal disorders · 2008Trial
- Diagnostic utility of the oesophageal balloon distension test in the evaluation of oesophageal chest pain.Alimentary pharmacology & therapeutics · 2012Article
- Recent advances in noncardiac chest pain in Korea.Gut and liver · 2012Article
- The hypersensitive esophagus: pathophysiology, evaluation, and treatment options.Current gastroenterology reports · 2010Review
- Investigation of esophageal sensation and biomechanical properties in functional chest pain.Neurogastroenterology and motility · 2010Article
- Clinical distinct features of noncardiac chest pain in young patients.Journal of neurogastroenterology and motility · 2010Article
- Patients dismissed from the hospital with a diagnosis of noncardiac chest pain: cardiac outcomes and health care utilization.Mayo Clinic proceedings · 2010Article
- Management of esophageal chest pain.Gastroenterology & hepatology · 2007Article
- Amitriptyline inhibits voltage-sensitive sodium currents in rat gastric sensory neurons.Digestive diseases and sciences · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The syndrome of angina-like pain with normal epicardial coronary vessels is a very common and expensive clinical problem. Patients suffering from this condition frequently present a diagnostic challenge. Cardiac and musculoskeletal disorders must be excluded prior to identifying the esophagus as the source of pain. The term "chest pain of undetermined origin" (UCP) has been proposed to refer to this condition. Esophageal dysmotility was previously considered a major source for chest pain; however, recent studies indicate that esophageal reflux is the most common cause of esophageal pain. Two controlled trials of acid suppressive agents in patients with chest pain have shown that omeprazole provides effective pain relief for the majority of these individuals. Visceral hyperalgesia and psychologic disturbances are also commonly noted in patients with UCP. Much remains to be learned about the etiology of visceral hyperalgesia and the precise role of psychologic abnormalities in these patients. Until further information is available, treatment with imipramine or trazodone has been shown to offer effective relief of chest pain for subgroups of patients with UCP. Psychologic intervention is also valuable in the management of some patients. Studies of other therapeutic regimens continue to be conducted.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.