ArticlePharmaceutical research2000
Controlled release of liposomes from biodegradable dextran microspheres: a novel delivery concept.
Article in Pharmaceutical research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 65 citations in OpenAlex.
- Nanoparticle-in-Hydrogel Delivery System for the Sequential Release of Two Drugs.Pharmaceutics · 2025Article
- Review
- Conversion of an Injectable MMP-Degradable Hydrogel into Core-Cross-Linked Micelles.Biomacromolecules · 2020Article
- Preparation and drug delivery of dextran-drug complex.Drug delivery · 2019Review
- Design of Hybrid Gels Based on Gellan-Cholesterol Derivative and P90G Liposomes for Drug Depot Applications.Gels (Basel, Switzerland) · 2017Article
- Gelation chemistries for the encapsulation of nanoparticles in composite gel microparticles for lung imaging and drug delivery.Biomacromolecules · 2014Article
- Viral and nonviral delivery systems for gene delivery.Advanced biomedical research · 2012Article
- Stereocomplexes Formed From Select Oligomers of Polymer d-lactic Acid (PDLA) and l-lactate May Inhibit Growth of Cancer Cells and Help Diagnose Aggressive Cancers-Applications of the Warburg Effect.Perspectives in medicinal chemistry · 2011Article
- Liquid-liquid two-phase systems for the production of porous hydrogels and hydrogel microspheres for biomedical applications: A tutorial review.Acta biomaterialia · 2011Review
- A review on composite liposomal technologies for specialized drug delivery.Journal of drug delivery · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo design liposome-loaded microspheres, which release the liposomes in a time-controlled manner and in intact form.
methodsLiposomes were encapsulated in biodegradable dextran-based microspheres, which were prepared using an aqueous two phase system consisting of poly(ethylene glycol) and methacrylated dextran. The effects of liposome size and membrane fluidity, microsphere water content, degree of methacrylate substitution, and type of dextran derivative used, on encapsulation efficiency, release, and integrity of the liposomes were investigated.
resultsLiposomes were entrapped in dextran-based microspheres quantitatively and with full preservation of their integrity. Liposomes with a low, as well as with a high membrane fluidity, were released from the microspheres in their intact form and with preservation of their size. Release kinetics depended only on the degradation rate of the microspheres. For rapidly degrading systems, pulsed release was observed and the time after which the pulse occurred (from 5 until 25 days) could be tailored by the gel characteristics such as initial water content, degree of methacrylate substitution, and type of hydrolytically sensitive spacer present in the cross-links. This delay time was not dependent on the size of the liposomes in the range studied (0.1-0.2 microm). Microspheres which degraded more slowly showed, after a certain delay time, sustained release of the liposomes extended up to 100 days.
conclusionsA novel drug delivery concept based on the encapsulation of liposomes in biodegradable dextran-based microspheres was designed. The system released the liposomes in intact form in a controlled way after a prolonged period of time.
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