ArticleThe Journal of comparative neurology2000
Differential effects of NGF and NT-3 on embryonic trigeminal axon growth patterns.
Article in The Journal of comparative neurology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 52 citations in OpenAlex.
- Culture of Primary Neurons from Dissociated and Cryopreserved Mouse Trigeminal Ganglion.Tissue engineering. Part C, Methods · 2023Article
- Nociceptor-Macrophage Interactions in Apical Periodontitis: How Biomolecules Link Inflammation with Pain.Biomolecules · 2023Review
- Aberrant early growth of individual trigeminal sensory and motor axons in a series of mouse genetic models of 22q11.2 deletion syndrome.Human molecular genetics · 2020Article
- Loss of neurotrophin-3 from smooth muscle disrupts vagal gastrointestinal afferent signaling and satiation.American journal of physiology. Regulatory, integrative and comparative physiology · 2013Article
- Developmental changes in the responsiveness of rat spiral ganglion neurons to neurotrophic factors in dissociated culture: differential responses for survival, neuritogenesis and neuronal morphology.Cell and tissue research · 2013Article
- Phospholipase D1 is an important regulator of bFGF-induced neurotrophin-3 expression and neurite outgrowth in H19-7 cells.Molecular neurobiology · 2012Article
- Rho GTPases as regulators of morphological neuroplasticity.Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft · 2011Review
- Brain-derived neurotrophic factor attracts geniculate ganglion neurites during embryonic targeting.Developmental neuroscience · 2010Article
- Differential regulation of axon outgrowth and reinnervation by neurotrophin-3 and neurotrophin-4 in the hippocampal formation.Experimental brain research · 2010Article
- Smooth-muscle-specific expression of neurotrophin-3 in mouse embryonic and neonatal gastrointestinal tract.Cell and tissue research · 2010Article
- Neocortical axon arbors trade-off material and conduction delay conservation.PLoS computational biology · 2010Article
- Factors regulating vagal sensory development: potential role in obesities of developmental origin.Physiology & behavior · 2008Article
- Prenatal exposure to elevated NT3 disrupts synaptic selectivity in the spinal cord.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Molecular determinants of the face map development in the trigeminal brainstem.The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology · 2006Review
- Differential Trk expression in explant and dissociated trigeminal ganglion cell cultures.Journal of neurobiology · 2005Article
- A chemoattractant role for NT-3 in proprioceptive axon guidance.PLoS biology · 2004Article
- Local neurotrophin effects on central trigeminal axon growth patterns.Brain research. Developmental brain research · 2004Article
- Morphometric analysis of embryonic rat trigeminal neurons treated with different neurotrophins.The anatomical record. Part A, Discoveries in molecular, cellular, and evolutionary biology · 2004Article
- Sensory neuron subtypes have unique substratum preference and receptor expression before target innervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Slit2, a branching-arborization factor for sensory axons in the Mammalian CNS.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2002Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
We examined the effects of neurotrophins nerve growth factor (NGF) and neurotrophin-3 (NT-3) on trigeminal axon growth patterns. Embryonic (E13-15) wholemount explants of the rat trigeminal pathway including the whisker pads, trigeminal ganglia, and brainstem were cultured in serum-free medium (SFM) or SFM supplemented with NGF or NT-3 for 3 days. Trigeminal axon growth patterns were analyzed with the use of lipophilic tracer DiI. In wholemount cultures grown in SFM, trigeminal axon projections, growth patterns, and differentiation of peripheral and central targets are similar to in vivo conditions. We show that in the presence of NGF, central trigeminal axons leave the tract and grow into the surrounding brainstem regions in the elongation phase without any branching. On the other hand, NT-3 promotes precocious development of short axon collaterals endowed with focal arbors along the sides of the central trigeminal tract. These neurotrophins also affect trigeminal axon growth within the whisker pad. Additionally, we cultured dissociated trigeminal ganglion cells in the presence of NGF, NT-3, or NGF+NT-3. The number of trigeminal ganglion cells, their size distribution under each condition were charted, and axon growth was analyzed following immunohistochemical labeling with TrkA and parvalbumin antibodies. In these cultures too, NGF led to axon elongation and NT-3 to axon arborization. Our in vitro analyses suggest that aside from their survival promoting effects, NGF and NT-3 can differentially influence axon growth patterns of embryonic trigeminal neurons.
Indexed as
Identifiers
10954840PMC4259054W1964242910What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.