ArticleNucleic acids research2000
Complex patterns of inheritance of an imprinted murine transgene suggest incomplete germline erasure.
Article in Nucleic acids research, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 49 citations in OpenAlex.
- Article
- The Promise of DNA Methylation in Understanding Multigenerational Factors in Autism Spectrum Disorders.Frontiers in genetics · 2022Review
- A spontaneous genetically induced epiallele at a retrotransposon shapes host genome function.eLife · 2021Article
- Intergenerational Transmission of DNA Methylation Signatures Associated with Early Life Stress.Current genomics · 2018Review
- Are striatal tyrosine hydroxylase interneurons dopaminergic?The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Reporter mice express green fluorescent protein at initiation of meiosis in spermatocytes.Genesis (New York, N.Y. : 2000) · 2014Article
- The use of epigenetic phenomena for the improvement of sheep and cattle.Frontiers in genetics · 2014Review
- The use of mouse models to study epigenetics.Cold Spring Harbor perspectives in biology · 2013Review
- Bridging the transgenerational gap with epigenetic memory.Trends in genetics : TIG · 2013Review
- Inducible mouse models illuminate parameters influencing epigenetic inheritance.Development (Cambridge, England) · 2013Article
- Understanding transgenerational epigenetic inheritance via the gametes in mammals.Nature reviews. Genetics · 2012Review
- Transgenerational epigenetic inheritance: more questions than answers.Genome research · 2010Review
- Transgene expression is associated with copy number and cytomegalovirus promoter methylation in transgenic pigs.PloS one · 2009Article
- Position effect variegation and imprinting of transgenes in lymphocytes.Nucleic acids research · 2008Article
- Widespread epigenetic abnormalities suggest a broad DNA methylation erasure defect in abnormal human sperm.PloS one · 2007Article
- A time- and dose-dependent STAT1 expression system.BMC biotechnology · 2006Article
- Article
- Discordance between genetic and epigenetic defects in pseudohypoparathyroidism type 1b revealed by inconsistent loss of maternal imprinting at GNAS1.American journal of human genetics · 2003Article
- Epimutations in Prader-Willi and Angelman syndromes: a molecular study of 136 patients with an imprinting defect.American journal of human genetics · 2003Article
- The marks, mechanisms and memory of epigenetic states in mammals.The Biochemical journal · 2001Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we report a transgenic mouse line that exhibits significant deviations from a classic pattern of parental imprinting. When the transgene is passed through the female germline, it is completely silenced in some offspring while in others expression is reduced. This variable expressivity does not appear to be the result of differences in the presence of unlinked modifiers. Female transmission of the transgene is associated with hypermethylation. The transgene is generally reactivated on passage through the male germline. Extended pedigrees reveal complex patterns of inheritance of the phenotype. The most likely explanation for this result is that the imprint is not completely erased and reset when passed through the germline of either sex. FISH analysis reveals that the transgene has integrated into chromosome 3 band E3, a region not known to carry imprinted genes, and the integration site shows no sign of allele-specific differential methylation. These findings, in conjunction with other recent work, raise the possibility that the introduction of foreign DNA into the mammalian genome, either through retrotransposition or transgenesis, may be associated with parental imprinting that is not always erased and reset during meiosis.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.