ArticleJournal of virology2000
Interaction of cellular proteins with the 5' end of Norwalk virus genomic RNA.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Article
- Recent insights into reverse genetics of norovirus.Virus research · 2023Review
- Human astroviruses: in silico analysis of the untranslated region and putative binding sites of cellular proteins.Molecular biology reports · 2019Review
- Article
- Functions of the 5' and 3' ends of calicivirus genomes.Virus research · 2015Review
- PTB binds to the 3' untranslated region of the human astrovirus type 8: a possible role in viral replication.PloS one · 2014Article
- Norovirus genome circularization and efficient replication are facilitated by binding of PCBP2 and hnRNP A1.Journal of virology · 2013Article
- Identification of RNA-protein interaction networks involved in the norovirus life cycle.Journal of virology · 2012Article
- Nucleolin interacts with the feline calicivirus 3' untranslated region and the protease-polymerase NS6 and NS7 proteins, playing a role in virus replication.Journal of virology · 2011Article
- Polypyrimidine tract binding protein functions as a negative regulator of feline calicivirus translation.PloS one · 2010Article
- Functional analysis of RNA structures present at the 3' extremity of the murine norovirus genome: the variable polypyrimidine tract plays a role in viral virulence.Journal of virology · 2010Article
- Model systems for the study of human norovirus Biology.Future virology · 2009Article
- Depletion of the poly(C)-binding proteins alphaCP1 and alphaCP2 from K562 cells leads to p53-independent induction of cyclin-dependent kinase inhibitor (CDKN1A) and G1 arrest.The Journal of biological chemistry · 2009Article
- Article
- Murine noroviruses comprising a single genogroup exhibit biological diversity despite limited sequence divergence.Journal of virology · 2007Article
- RNA viruses redirect host factors to better amplify their genome.Advances in virus research · 2005Article
- Viral and cellular proteins involved in coronavirus replication.Current topics in microbiology and immunology · 2005Review
- La, PTB, and PAB proteins bind to the 3(') untranslated region of Norwalk virus genomic RNA.Biochemical and biophysical research communications · 2003Article
- Identification of mRNAs associated with alphaCP2-containing RNP complexes.Molecular and cellular biology · 2003Article
- The genome of hawaii virus and its relationship with other members of the caliciviridae.Virus genes · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The lack of a susceptible cell line and an animal model for Norwalk virus (NV) infection has prompted the development of alternative strategies to generate in vitro RNAs that approximate the authentic viral genome. This approach has allowed the study of viral RNA replication and gene expression. In this study, using mobility shift and cross-linking assays, we detected several cellular proteins from HeLa and CaCo-2 cell extracts that bind to, and form stable complexes with, the first 110 nucleotides of the 5' end of NV genomic RNA, a region previously predicted to form a double stem-loop structure. These proteins had molecular weights similar to those of the HeLa cellular proteins that bind to the internal ribosomal entry site of poliovirus RNA. HeLa proteins La, PCBP-2, and PTB, which are important for poliovirus translation, and hnRNP L, which is possibly implicated in hepatitis C virus translation, interact with NV RNA. These protein-RNA interactions are likely to play a role in NV translation and/or replication.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.