ArticleJournal of virology2000
Avian nephritis virus (ANV) as a new member of the family Astroviridae and construction of infectious ANV cDNA.
Article in Journal of virology, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 67 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
67 citing papers in PubMed, 1 synthesis or guideline pooled it, 174 citations in OpenAlex.
- Pooled it
- Emerging and Re-Emerging Viral Infections in Poultry: Integrating Traditional and AI-Based Control Strategies.Current microbiology · 2026Review
- Maternal antibody-mediated protection against chicken astrovirus: efficacy of novel inactivated vaccine.Veterinary research communications · 2026Article
- The enteric virus associated with baby chick nephropathy in Japan was genetically identified as chicken astrovirus, not avian nephritis virus.The Journal of veterinary medical science · 2026Article
- First detection and diversity of astroviruses in wild migratory birds of Sakhalin Island, North Pacific.Virus genes · 2025Article
- Simultaneous detection and partial molecular characterization of five RNA viruses associated with enteric disease in chickens: chicken astrovirus, avian nephritis virus, infectious bronchitis virus, avian rotavirus a and avian orthoreovirus, via multiplex RT-qPCR.Frontiers in veterinary science · 2025Article
- Porcine Astrovirus Infection in Brains of Pigs in Korea.Viruses · 2024Article
- Development of a fast and sensitive RT-qPCR assay based on SYBR® green for diagnostic and quantification of Avian Nephritis Virus (ANV) in chickens affected with enteric disease.BMC veterinary research · 2024Article
- Molecular characteristics and pathogenicity of a novel chicken astrovirus variant.Veterinary research · 2023Article
- Chicken Astro virus (CAstV): Isolation and characterization of new strains in broiler flocks with poor performance.Veterinary research communications · 2023Article
- Identification and characterization of a novel avian nephritis virus variant in chickens with enteritis in Hunan province, China.Archives of virology · 2023Article
- Genetic characterization of canine astrovirus in non-diarrhea dogs and diarrhea dogs in Vietnam and Thailand reveals the presence of a unique lineage.Frontiers in veterinary science · 2023Article
- The Genomic and Genetic Evolution Analysis of Rabbit Astrovirus.Veterinary sciences · 2022Article
- A Review of the Emerging Poultry Visceral Gout Disease Linked to Avian Astrovirus Infection.International journal of molecular sciences · 2022Review
- Bovine Astrovirus-A Comprehensive Review.Viruses · 2022Review
- An Insight into the Molecular Characteristics and Associated Pathology of Chicken Astroviruses.Viruses · 2022Review
- Pathogenesis of Chicken Astrovirus Related Illnesses.Frontiers in veterinary science · 2022Review
- An outbreak of neonatal enteritis in buffalo calves associated with astrovirus.Journal of veterinary science · 2021Article
- Genomic features of first bovine astrovirus detected in Egypt.Virusdisease · 2021Article
- Beyond the Gastrointestinal Tract: The Emerging and Diverse Tissue Tropisms of Astroviruses.Viruses · 2021Review
7 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The complete RNA genome of the avian nephritis virus (ANV) associated with acute nephritis in chickens has been molecularly cloned and sequenced. Excluding the poly(A) tail, the genome comprises 6,927 nucleotides and contains three sequential open reading frames (ORFs). The first ORF (ORF 1a) contains a sequence encoding a serine protease motif, and the second ORF (ORF 1b) has a sequence encoding an RNA-dependent RNA polymerase. ORF 1a may be linked to the second ORF by a ribosomal frameshifting mechanism. The third ORF (ORF 2) may encode the virion structural proteins as a polyprotein precursor. Two RNAs, probably genonic and subgenonic RNA (7.5 and 3.0 kb), were detected in the cytoplasm of ANV-infected cells. ANV and human astroviruses have the same genonic organization, and both are characterized by the presence of two RNA bands. The amino acid homologies of the products of ORF 1a, 1b, and 2 were 20.3, 41.9, and 25.8% to products of the corresponding ORFs of human astrovirus serotype 1 (A/88 Newcastle strain). We have constructed a genonic-length cDNA clone of ANV to test whether the in vitro transcript is infectious. When a chicken kidney cell culture was transfected with RNA transcribed in vitro and the cDNA clone, infectious virus was produced with cytopathic effects in the absence of trypsin. These observations suggested that the ANV (G-4260 strain) is a new genus of the family Astroviridae.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.