Evidence map›Paper›PMID 10952722›Full record

ArticleThe Journal of experimental medicine2000

Host-virus interactions during malaria infection in hepatitis B virus transgenic mice.

V Pasquetto, L G Guidotti, K Kakimi, M Tsuji, F V Chisari

Abstract read
In one paragraph

Article in The Journal of experimental medicine, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Macrophage Phenotypes and Hepatitis B Virus Infection.Journal of clinical and translational hepatology · 2020
    Review
  4. Article
  5. Article
  6. Review
  7. HBV Core Protein Enhances Cytokine Production.Diseases (Basel, Switzerland) · 2015
    Article
  8. The chimpanzee model for hepatitis B virus infection.Cold Spring Harbor perspectives in medicine · 2015
    Review
  9. Review
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

V PasquettoDepartment of Molecular and Experimental Medicine, The Scripps Research Institute, La Jolla, California 92037, USA.
L G Guidotti
K Kakimi
M Tsuji
F V Chisari

Funding

Regulation of HBV Replication by the Immune SystemR01AI040696 · NIAID · SCRIPPS RESEARCH INSTITUTE, THE · PI GUIDOTTI, LUCA G. · 1997 to 2012
$5.2M
ADENOVIRUS--AN EFFICIENT VECTOR OF ANTIMALARIA IMMUNITYR29AI040656 · NIAID · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI TSUJI, MORIYA · 1997 to 2001
$225k
PATHOGENESIS OF HEPATITIS B IN TRANSGENIC MICER37CA040489 · NCI · SCRIPPS RESEARCH INSTITUTE · PI CHISARI, FRANCIS VINCENT · 1990 to 1999
–
NCI NIH HHS R37 CA040489NCI NIH HHS R37 CA40489NIAID NIH HHS R01 AI040696NIAID NIH HHS R01 AI40696
6 · The paper itself

Abstract

We have previously shown that hepatitis B virus (HBV) replication is abolished in the liver of HBV transgenic mice by inflammatory cytokines induced by HBV-specific cytotoxic T cells and during unrelated viral infections of the liver. We now report that intrahepatic HBV replication is also inhibited in mice infected by the malaria species Plasmodium yoelii 17X NL. P. yoelii infection triggers an intrahepatic inflammatory response characterized by the influx of natural killer cells, macrophages, and T cells. During this process, interferon (IFN)-gamma and IFN-alpha/beta suppress HBV gene expression and replication in the liver. Collectively, the data suggest that malaria infection might influence the course and pathogenesis of HBV infection in coinfected humans.

Indexed as

Alanine TransaminaseAnimalsBlotting, NorthernCytokinesHepatitis BHepatitis B virusHumansInterferonsLiverMacrophagesMalariaMiceMice, TransgenicPlasmodium yoeliiT-LymphocytesVirus ReplicationAlanine TransaminaseCytokinesInterferons

Identifiers

PMID10952722
PMCPMC2193244

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-SA
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.