Trial reportArchives of disease in childhood. Fetal and neonatal edition2000
Maturation of primary and permanent teeth in preterm infants.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04572581 (Use of Human Milk-Based Diet in the Late Preterm and Term Infant in the Neonatal Intensive Care Unit), which is not on this map. Cited by 11 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Use of Human Milk-Based Diet in the Late Preterm and Term Infant in the Neonatal Intensive Care Unit: A Pilot Randomized Controlled Trial
Who cites it
11 citing papers in PubMed, 3 syntheses or guidelines pooled it, 47 citations in OpenAlex.
- Vitamin D supplementation for prevention of vitamin D deficiency in preterm and low birth weight infants.The Cochrane database of systematic reviews · 2026Pooled it
- Relationship between preterm, low birth weight and early childhood caries: a meta-analysis of the case-control and cross-sectional study.Bioscience reports · 2020Pooled it
- Multidisciplinary guidelines for the care of late preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2013Guideline
- Timing of primary maxillary tooth eruption in preterm compared to term infants: a retrospective longitudinal cohort study.BMC oral health · 2026Observational
- Timing of Primary Tooth Eruption in Infants Observed by Their Parents.Children (Basel, Switzerland) · 2023Article
- General correlation between neonatal factors, primary and permanent tooth eruption and their interrelation in a population in german orthodontic practices.BMC oral health · 2023Article
- Relationship of Vitamin D Deficiency with Cervical Vertebral Maturation and Dental Age in Adolescents: A Cross-Sectional Study.International journal of dentistry · 2022Article
- The impact of premature birth on dental maturation in the permanent dentition.Clinical oral investigations · 2019Article
- Relationship between malnutrition and the number of permanent teeth in Filipino 10- to 13-year-olds.BioMed research international · 2013Article
- Preterm Birth: A Primary Etiological Factor for Delayed Oral Growth and Development.International journal of clinical pediatric dentistryReview
- Influence of Birth Characteristics and Feeding Practices on Eruption of Primary Teeth in Children: A Preliminary Cross-sectional Observational Study.International journal of clinical pediatric dentistryArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo elucidate the development of primary and permanent teeth and to interpret the effect of different calcium, phosphorus, and vitamin D supplementation in the neonatal period on dental maturation in preterm children.
methodsPreterm infants were randomised to four groups to receive a vitamin D dose of 500 or 1000 IU/day and calcium and phosphorus supplemented or unsupplemented breast milk. The maturity of the primary and permanent teeth was recorded in 30 preterm children. Sixty children aged 2 years and 60 children aged 9-11 years served as controls. Bone mineral content/density was assessed in the preterm infants.
resultsThe median (range) corrected teething age was 7 (2-16) months in preterm infants and 6 (2-12) months in controls (p = 0.43). The median (range) number of erupted teeth at 2 years of age was 16 (11-19) in preterm infants and 16 (12-20) in controls (p = 0.16). Maturation of the permanent teeth in the preterm infants was not delayed compared with the controls (mean Demirjian SDS 0.16 v 0.49, p = 0.14). Early dietary intake of either mineral or vitamin D did not affect maturation of the primary dentition in preterm children. Children receiving the higher vitamin D dose in the neonatal period had more mature permanent dentition than those receiving the lower dose, but mineral intake did not affect maturation of the permanent teeth. Dental maturation did not correlate with bone mineral status.
conclusionsThis is the first longitudinal study to follow primary and permanent tooth maturation in the same preterm children. Premature birth has no appreciable late sequelae in tooth maturation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.