Trial reportArchives of disease in childhood. Fetal and neonatal edition2000
Randomised trial of fluid restriction in ventilated very low birthweight infants.
Trial report in Archives of disease in childhood. Fetal and neonatal edition, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 3 syntheses or guidelines pooled it, 83 citations in OpenAlex.
- Association between fluid overload and mortality in newborns: a systematic review and meta-analysis.Pediatric nephrology (Berlin, Germany) · 2022Pooled it
- Restricted versus liberal water intake for preventing morbidity and mortality in preterm infants.The Cochrane database of systematic reviews · 2014Pooled it
- Early volume expansion for prevention of morbidity and mortality in very preterm infants.The Cochrane database of systematic reviews · 2004Pooled it
- Albumin versus normal saline for dehydrated term infants with metabolic acidosis due to acute diarrhea.Journal of perinatology : official journal of the California Perinatal Association · 2009Trial
- Randomized trial of sterile water by gavage drip in the fluid management of extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2009Trial
- Strategies for the prevention of bronchopulmonary dysplasia.Frontiers in pediatrics · 2024Review
- A Systematic Review: Is Early Fluid Restriction in Preterm Neonates Going to Prevent Bronchopulmonary Dysplasia?Cureus · 2023Review
- Association between Fluid Balance and Treatment Outcome of Ibuprofen for Patent Ductus Arteriosus in Preterm Infants.Reviews in cardiovascular medicine · 2023Article
- Postnatal fluid balance - it's time to pay attention.Journal of perinatology : official journal of the California Perinatal Association · 2022Article
- Learning to live with patency of the ductus arteriosus in preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2011Review
- Fluid regimens in the first week of life may increase risk of patent ductus arteriosus in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2008Article
- Association between early postnatal weight loss and death or BPD in small and appropriate for gestational age extremely low-birth-weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2007Article
- A scoring system to predict chronic oxygen dependency.European journal of pediatrics · 2007Article
- Lung volumes in infants who had mild to moderate bronchopulmonary dysplasia.European journal of pediatrics · 2005Article
- Prediction of outcome from the chest radiograph appearance on day 7 of very prematurely born infants.European journal of pediatrics · 2004Article
- Current perspectives on the prevention and management of chronic lung disease in preterm infants.Paediatric drugs · 2003Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundFluid restriction has been reported to improve survival of infants without chronic lung disease (CLD), but it remains unknown whether it reduces CLD in a population at high risk of CLD routinely exposed to antenatal steroids and postnatal surfactant without increasing other adverse outcomes.
aimTo investigate the impact of fluid restriction on the outcome of ventilated, very low birthweight infants. STUDY
designA randomised trial of two fluid input levels in the perinatal period was performed. A total of 168 ventilated infants (median gestational age 27 weeks (range 23-33)) were randomly assigned to receive standard volumes of fluid (60 ml/kg on day 1 progressing to 150 ml/kg on day 7) or be restricted to about 80% of standard input.
resultsSimilar proportions of infants on the two regimens had CLD beyond 28 days (56% v 51%) and 36 weeks post conceptional age (26% v 25%), survived without oxygen dependency at 28 days (31% v 27%) and 36 weeks post conceptional age (58% v 52%), and developed acute renal failure. There were no statistically significant differences between other outcomes, except that fewer of the restricted group (19% v 43%) required postnatal steroids (p < 0.01). In the trial population overall, duration of oxygen dependency related significantly to the colloid (p < 0.01), but not crystalloid, input level; after adjustment for specified covariates, the hazard ratio was 1.07 (95% confidence interval 1.02 to 1.13).
conclusionsIn ventilated, very low birthweight infants, fluid restriction in the perinatal period neither reduces CLD nor increases other adverse outcomes. Colloid infusion, however, is associated with increased duration of oxygen dependency.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.