ArticleAntimicrobial agents and chemotherapy2000
Antimalarial activities of aminooxy compounds.
Article in Antimicrobial agents and chemotherapy, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 26 citations in OpenAlex.
- Plant amino acid analogues as antimicrobial agents.Amino acids · 2025Review
- Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum.Nature communications · 2015Article
- Studies of Antimicrobial Activities of some 4-Thiazolidinone Fused Pyrimidines, [1,5]-Benzodiazepines and their Oxygen Substituted Hydroxylamine Derivatives.Indian journal of pharmaceutical sciences · 2010Article
- Antimalarial drug targets in Plasmodium falciparum predicted by stage-specific metabolic network analysis.BMC systems biology · 2010Article
- Purification, crystallization and preliminary X-ray analysis of the aspartate aminotransferase of Plasmodium falciparum.Acta crystallographica. Section F, Structural biology and crystallization communications · 2010Article
- Synthesis, pharmacology, and cell biology of sn-2-aminooxy analogues of lysophosphatidic acid.Organic letters · 2008Article
- Branched-chain amino acid aminotransferase and methionine formation in Mycobacterium tuberculosis.BMC microbiology · 2004Article
- Methionine regeneration and aminotransferases in Bacillus subtilis, Bacillus cereus, and Bacillus anthracis.Journal of bacteriology · 2003Article
- Methionine regeneration and aspartate aminotransferase in parasitic protozoa.Journal of bacteriology · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
Twenty-three aminooxy compounds have been examined for their ability to inhibit the growth of the malaria parasite Plasmodium falciparum in vitro. Eight of these compounds were found to have 50% inhibitory concentrations less than 10 microM, with the best drugs being canaline (the aminooxy analogue of ornithine) and CGP51905A at 297 +/- 23.6 nM and 242 +/- 18.8 nM, respectively. Canaline was also assayed in combination with the ornithine decarboxylase inhibitor difluoromethylornithine, and the two drugs were found to be synergistic in antimalarial activity.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.