ArticleNature2000
Different initiation of pre-TCR and gammadeltaTCR signalling.
Article in Nature, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 155 citations in OpenAlex.
- Developing T cells form an immunological synapse for passage through the β-selection checkpoint.The Journal of cell biology · 2021Article
- Simulating T Cell Receptor Evolution: Sequence-Structure-Dynamics-Function Relationships.Biophysical journal · 2018Article
- Structural Conservation and Effects of Alterations in T Cell Receptor Transmembrane Interfaces.Biophysical journal · 2018Article
- Transcription factors and target genes of pre-TCR signaling.Cellular and molecular life sciences : CMLS · 2015Review
- Placing ion channels into a signaling network of T cells: from maturing thymocytes to healthy T lymphocytes or leukemic T lymphoblasts.BioMed research international · 2015Review
- Enforcement of γδ-lineage commitment by the pre-T-cell receptor in precursors with weak γδ-TCR signals.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Increased membrane cholesterol in lymphocytes diverts T-cells toward an inflammatory response.PloS one · 2012Article
- Germ-line elimination of electric charge on pre-T-cell receptor (TCR) impairs autonomous signaling for beta-selection and TCR repertoire formation.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- αβ versus γδ fate choice: counting the T-cell lineages at the branch point.Immunological reviews · 2010Review
- Article
- gammadeltaTCR ligands and lineage commitment.Seminars in immunology · 2010Review
- Alphabeta versus gammadelta lineage choice at the first TCR-controlled checkpoint.Current opinion in immunology · 2010Review
- Differential subcellular localization regulates c-Cbl E3 ligase activity upon Notch3 protein in T-cell leukemia.Oncogene · 2010Article
- Molecular mechanisms that control mouse and human TCR-alphabeta and TCR-gammadelta T cell development.Seminars in immunopathology · 2008Review
- Article
- Differential synergy of Notch and T cell receptor signaling determines alphabeta versus gammadelta lineage fate.The Journal of experimental medicine · 2006Article
- Involvement of Prep1 in the alphabeta T-cell receptor T-lymphocytic potential of hematopoietic precursors.Molecular and cellular biology · 2005Article
- PKC theta mediates pre-TCR signaling and contributes to Notch3-induced T-cell leukemia.Oncogene · 2005Article
- Function of the Src-family kinases, Lck and Fyn, in T-cell development and activation.Oncogene · 2004Review
- Defined alphabeta T cell receptors with distinct ligand specificities do not require those ligands to signal double negative thymocyte differentiation.The Journal of experimental medicine · 2004Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lineage choice is of great interest in developmental biology. In the immune system, the alphabeta and gammadelta lineages of T lymphocytes diverge during the course of the beta-, gamma- and delta-chain rearrangement of T-cell receptor (TCR) genes that takes place within the same precursor cell and which results in the formation of the gammadeltaTCR or pre-TCR proteins. The pre-TCR consists of the TCRbeta chain covalently linked to the pre-TCRalpha protein, which is present in immature but not in mature T cells which instead express the TCRalpha chain. Animals deficient in pre-TCRalpha have few alphabeta lineage cells but an increased number of gammadelta T cells. These gammadelta T cells exhibit more extensive TCRbeta rearrangement than gammadelta T cells from wild-type mice. These observations are consistent with the idea that different signals emanating from the gammadeltaTCR and pre-TCR instruct lineage commitment. Here we show, by using confocal microscopy and biochemistry to analyse the initiation of signalling, that the pre-TCR but not the gammadeltaTCR colocalizes with the p56lck Src kinase into glycolipid-enriched membrane domains (rafts) apparently without any need for ligation. This results in the phosphorylation of CD3epsilon and Zap-70 signal transducing molecules. The results indicate clear differences between pre-TCR and gammadeltaTCR signalling.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.