ArticleOncogene2000
The contribution of the RING finger domain of MDM2 to cell cycle progression.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
24 citing papers in PubMed, 35 citations in OpenAlex.
- Article
- The roles of E3 ubiquitin ligases in cancer progression and targeted therapy.Clinical and translational medicine · 2023Review
- RNA Sequencing Analysis of Gene Expression by Electroacupuncture in Guinea Pig Gallstone Models.Evidence-based complementary and alternative medicine : eCAM · 2022Article
- Review
- Delineating Crosstalk Mechanisms of the Ubiquitin Proteasome System That Regulate Apoptosis.Frontiers in cell and developmental biology · 2018Review
- Triptolide has anticancer and chemosensitization effects by down-regulating Akt activation through the MDM2/REST pathway in human breast cancer.Oncotarget · 2016Article
- Characterization of cancer-associated missense mutations in MDM2.Molecular & cellular oncology · 2016Article
- Article
- Limiting the power of p53 through the ubiquitin proteasome pathway.Genes & development · 2014Review
- E3Net: a system for exploring E3-mediated regulatory networks of cellular functions.Molecular & cellular proteomics : MCP · 2012Article
- Mdm2 links genotoxic stress and metabolism to p53.Protein & cell · 2010Review
- The novel mouse Polo-like kinase 5 responds to DNA damage and localizes in the nucleolus.Nucleic acids research · 2010Article
- Article
- Apoptosome-deficient cells lose cytochrome c through proteasomal degradation but survive by autophagy-dependent glycolysis.Molecular biology of the cell · 2008Article
- MDMX promotes proteasomal turnover of p21 at G1 and early S phases independently of, but in cooperation with, MDM2.Molecular and cellular biology · 2008Article
- The RING finger domain of MDM2 is essential for MDM2-mediated TGF-beta resistance.Molecular biology of the cell · 2007Article
- Polo-like kinase 3 is required for entry into S phase.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- The histone acetyltransferases CBP/p300 are degraded in NIH 3T3 cells by activation of Ras signalling pathway.The Biochemical journal · 2006Article
- Regulation of androgen receptor and histone deacetylase 1 by Mdm2-mediated ubiquitylation.Nucleic acids research · 2005Article
- Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The MDM2 oncoprotein binds to p53 and abrogates p53-mediated G1 arrest and apoptosis. We show that MDM2 over-expression accelerates cell cycle progression of RPM12650 cells by overcoming the negative effect of endogenous wild type p53 at the G1/S checkpoint. The interaction with p53 and transcription inhibition are necessary but not sufficient. The RING finger domain of MDM2 is also required for the positive effect of MDM2 on the cell cycle. Surprisingly, several point mutants in the zinc binding sites of the RING finger are fully competent for cell cycle stimulation even though they abolish MDM2-directed degradation of p53 and MDM2 E3-ligase activity. In contrast, alterations in and around the cryptic nucleolar localization sequence (KR motif) inhibit MDM2-mediated cell cycle progression as well as p53 degradation and MDM2 E3 ligase activity. We found that all the RING mutants decrease inhibition of both p53 dependent reporters and endogenous p21CIP1/WAF1/SDI1. These results indicate that the RING finger of MDM2 has a role in the regulation of the cell cycle that is independent of p53 degradation and endogenous p21CIP1/WAF1/SDI1 regulation.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.