ArticleOncogene2000
LUCA-15-encoded sequence variants regulate CD95-mediated apoptosis.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 56 citations in OpenAlex.
- Elucidating the role of RBM5 in osteoclastogenesis: a novel potential therapeutic target for osteoporosis.BMC musculoskeletal disorders · 2023Article
- Whole-genome-scale identification of novel non-protein-coding RNAs controlling cell proliferation and survival through a functional forward genetics strategy.Scientific reports · 2022Article
- Role of RNA-binding protein 5 in the diagnosis and chemotherapeutic response of lung cancer.Oncology letters · 2019Review
- Article
- Post-transcriptional regulation of Rbm5 expression in undifferentiated H9c2 myoblasts.In vitro cellular & developmental biology. Animal · 2016Article
- Overexpression of RBM5 induces autophagy in human lung adenocarcinoma cells.World journal of surgical oncology · 2016Article
- Mitochondria Biogenesis and Bioenergetics Gene Profiles in Isogenic Prostate Cells with Different Malignant Phenotypes.BioMed research international · 2016Article
- Insight into the role of alternative splicing within the RBM10v1 exon 10 tandem donor site.BMC research notes · 2015Article
- Differential downregulation of Rbm5 and Rbm10 during skeletal and cardiac differentiation.In vitro cellular & developmental biology. Animal · 2014Article
- Tumor suppressor gene RBM5 delivered by attenuated Salmonella inhibits lung adenocarcinoma through diverse apoptotic signaling pathways.World journal of surgical oncology · 2013Article
- 3p21.3 tumor suppressor gene RBM5 inhibits growth of human prostate cancer PC-3 cells through apoptosis.World journal of surgical oncology · 2012Article
- The tumor suppressor gene RBM5 inhibits lung adenocarcinoma cell growth and induces apoptosis.World journal of surgical oncology · 2012Article
- RBM10 Modulates Apoptosis and Influences TNF-α Gene Expression.Journal of cell death · 2012Article
- Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged.Genes & development · 2010Review
- RACK-1 overexpression protects against goniothalamin-induced cell death.Toxicology letters · 2009Article
- GAS5, a non-protein-coding RNA, controls apoptosis and is downregulated in breast cancer.Oncogene · 2009Article
- Dysregulated expression of Fau and MELK is associated with poor prognosis in breast cancer.Breast cancer research : BCR · 2009Article
- Up-regulation of the proapoptotic caspase 2 splicing isoform by a candidate tumor suppressor, RBM5.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- The two single nucleotide polymorphisms in the H37/RBM5 tumour suppressor gene at 3p21.3 correlated with different subtypes of non-small cell lung cancers.Lung cancer (Amsterdam, Netherlands) · 2007Article
- The antiapoptotic RBM5/LUCA-15/H37 gene and its role in apoptosis and human cancer: research update.TheScientificWorldJournal · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
Abstract
Using an expression cloning system to discover novel genes involved in apoptosis, we identified a 326 bp bone marrow cDNA fragment (termed Je2) that suppresses, upon transfection, CD95-mediated apoptosis in Jurkat T cells. Sequence homology revealed that Je2 maps to 3p21.3, to an intronic region of the candidate TSG LUCA-15 locus. It represents, in fact, an antisense transcript to the 3'-UTR of two novel splice variants of this gene. Overexpression of sequence representing one of these splice variants (a 2.6 kb cDNA termed Clone 26), inhibited proliferation of Jurkat cells and sensitized them to CD95-mediated apoptosis. This study therefore implicates the LUCA-15 gene locus in the control of apoptosis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.