ArticleOncogene2000
Distinct chromosomal abnormality pattern in primary liver cancer of non-B, non-C patients.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 102 citations in OpenAlex.
- Detecting Liver Cancer Using Cell-Free DNA Fragmentomes.Cancer discovery · 2023Article
- Genome and transcriptome profiling of fibrolamellar hepatocellular carcinoma demonstrates p53 and IGF2BP1 dysregulation.PloS one · 2017Article
- Methylation-regulated miR-124-1 suppresses tumorigenesis in hepatocellular carcinoma by targeting CASC3.Oncotarget · 2016Article
- Hepatocellular carcinoma.Cold Spring Harbor perspectives in medicine · 2015Review
- The genomic landscape of fibrolamellar hepatocellular carcinoma: whole genome sequencing of ten patients.Oncotarget · 2015Article
- Genomic analysis of fibrolamellar hepatocellular carcinoma.Human molecular genetics · 2015Article
- Role of hepatitis B virus DNA integration in human hepatocarcinogenesis.World journal of gastroenterology · 2014Review
- MicroRNAs as therapeutic strategy for hepatitis B virus-associated hepatocellular carcinoma: current status and future prospects.World journal of gastroenterology · 2014Review
- Detection of a recurrent DNAJB1-PRKACA chimeric transcript in fibrolamellar hepatocellular carcinoma.Science (New York, N.Y.) · 2014Article
- Quasispecies structure, cornerstone of hepatitis B virus infection: mass sequencing approach.World journal of gastroenterology · 2013Review
- Recurrent targeted genes of hepatitis B virus in the liver cancer genomes identified by a next-generation sequencing-based approach.PLoS genetics · 2012Article
- Fibrolamellar carcinoma: 2012 update.Scientifica · 2012Review
- ARID2: a new tumor suppressor gene in hepatocellular carcinoma.Oncotarget · 2011Review
- Update on the Risk of Hepatocellular Carcinoma in Chronic Hepatitis B Virus Infection.Current hepatitis reports · 2011Article
- Cell cycle biology of fibrolamellar hepatocellular carcinoma.International journal of clinical and experimental pathology · 2010Article
- Gain of miR-151 on chromosome 8q24.3 facilitates tumour cell migration and spreading through downregulating RhoGDIA.Nature cell biology · 2010Article
- Molecular genetics of hepatocellular neoplasia.American journal of translational research · 2010Article
- Liver cell transformation in chronic HBV infection.Viruses · 2009Article
- Predominant modifier of extreme liver cancer susceptibility in C57BR/cdJ female mice localized to 6 Mb on chromosome 17.Carcinogenesis · 2009Article
- Natural history of hepatitis-related hepatocellular carcinoma.World journal of gastroenterology · 2008Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To discriminate among the chromosomal abnormalities associated with the etiology of hepatocellular carcinoma (HCC), we performed a comparative genomic hybridization (CGH) analysis on 34 HCCs resected on non-cirrhotic livers from patients serologically negative for both hepatitis B (HBV) and C (HCV) viruses. The results were compared to those of a previous analysis of 50 HCCs selected on the basis of their positivity for HBV infection. The majority of the abnormalities found in the HBV positive cases (losses of chromosome arms 1p, 8p, 6q, 13q and 14q and gains of 1q, 8q, 6p and 17q) were similarly detected in the virus negative specimens. In contrast, a significant decrease (40% on average) was observed for losses at 4q, 16q and 17p in non-viral HCC samples, suggesting that these abnormalities are tightly associated with HBV infection. Thus, in addition to a common pathway towards malignancy, a subset of alterations may preferentially contribute to virus-induced carcinogenesis. In a parallel CGH study of 10 fibrolamellar carcinomas, a rare subtype of HCC, we found in six out of the seven informative cases, gains of chromosome arm 1q. This region, which is also preferentially amplified in non fibrolamellar tumors (58%), may contain an essential proto-oncogene commonly implicated in liver carcinogenesis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.