ArticleOncogene2000
Switch from p53 to MDM2 as differentiating human keratinocytes lose their proliferative potential and increase in cellular size.
Article in Oncogene, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
27 citing papers in PubMed, 66 citations in OpenAlex.
- History-dependent switch-like differentiation of keratinocytes in response to skin barrier damage.PLoS computational biology · 2025Article
- DNA damage signalling histone H2AX is required for tumour growth.Cell death discovery · 2024Article
- ZetaSuite: computational analysis of two-dimensional high-throughput data from multi-target screens and single-cell transcriptomics.Genome biology · 2022Article
- Molecular mapping of interstitial lung disease reveals a phenotypically distinct senescent basal epithelial cell population.JCI insight · 2021Article
- Article
- The DNA damage response links human squamous proliferation with differentiation.The Journal of cell biology · 2020Article
- Sublethal UV irradiation induces squamous differentiation via a p53-independent, DNA damage-mitosis checkpoint.Cell death & disease · 2018Article
- Full-Length Isoforms of Kaposi's Sarcoma-Associated Herpesvirus Latency-Associated Nuclear Antigen Accumulate in the Cytoplasm of Cells Undergoing the Lytic Cycle of Replication.Journal of virology · 2017Article
- Asymmetric stem-cell division ensures sustained keratinocyte hyperproliferation in psoriatic skin lesions.International journal of molecular medicine · 2016Article
- Cancer stem cells and cell size: A causal link?Seminars in cancer biology · 2015Review
- Electrical stimulation enhances epidermal proliferation in human cutaneous wounds by modulating p53-SIVA1 interaction.The Journal of investigative dermatology · 2015Article
- Genetic and molecular aspects of Helicobacter pylori in gastritis, pre- cancerous conditions and gastric adenocrcinoma.Gastroenterology and hepatology from bed to bench · 2015Review
- The mysterious human epidermal cell cycle, or an oncogene-induced differentiation checkpoint.Cell cycle (Georgetown, Tex.) · 2012Review
- Article
- Mathematical modeling of the impact of actin and keratin filaments on keratinocyte cell spreading.Biophysical journal · 2012Article
- hTERT, MYC and TP53 deregulation in gastric preneoplastic lesions.BMC gastroenterology · 2012Article
- It Takes 15 to Tango: Making Sense of the Many Ubiquitin Ligases of p53.Genes & cancer · 2012Article
- The histone methyltransferase Setd8 acts in concert with c-Myc and is required to maintain skin.The EMBO journal · 2012Article
- A cell cycle role for the epigenetic factor CTCF-L/BORIS.PloS one · 2012Article
- IRF6 is a mediator of Notch pro-differentiation and tumour suppressive function in keratinocytes.The EMBO journal · 2011Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
p53 transcription factor is mutated in most skin cell carcinomas and in more than 50% of all human malignancies. One of its transcriptional targets is MDM2, which in turn down-regulates p53. The role of the p53/MDM2 regulatory loop upon genotoxic stress is well documented, but less is known about its role in normal tissue homeostasis. We have explored this pathway during the different transitions of the human epidermal differentiation programme and after isolating stem cells, transit amplifying cells or differentiating cells from epidermis. Maximum expression of p53 was found in proliferating keratinocytes. A striking and transient induction of MDM2 and a down-modulation of p53 characterized the transition from proliferation to differentiation in primary human keratinocytes. These changes were delayed in late differentiating carcinoma cells, and were clearly different in suspended primary fibroblasts. Interestingly, these changes correlated with an increase in cell size, at the time of irreversible commitment to differentiation. Induction of MDM2 was also associated with suppression of proliferation in normal, or hyperproliferative, psoriatic epidermis. Moreover, both proteins were induced as keratinocytes were driven to leave the stem cell compartment by c-Myc activation. Overall, our results show a critical regulation of the p53/MDM2 pathway at the epidermal transition from proliferation to differentiation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.