ArticleInfection and immunity2000
Presence of phosphorylcholine on a filarial nematode protein influences immunoglobulin G subclass response to the molecule by an interleukin-10-dependent mechanism.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 56 citations in OpenAlex.
- Allotype-Dependent Responses to the Vaccine Candidate Thrombospondin-Like Protein of Dictyocaulus viviparus in Calves.Parasite immunology · 2025Article
- The parasitic worm product ES-62 protects the osteoimmunology axis in a mouse model of obesity-accelerated ageing.Frontiers in immunology · 2022Article
- Helminth Glycans at the Host-Parasite Interface and Their Potential for Developing Novel Therapeutics.Frontiers in molecular biosciences · 2021Review
- Helminth Immunomodulation in Autoimmune Disease.Frontiers in immunology · 2017Review
- Article
- Phosphocholine-Specific Antibodies Improve T-Dependent Antibody Responses against OVA Encapsulated into Phosphatidylcholine-Containing Liposomes.Frontiers in immunology · 2016Article
- Lessons from helminth infections: ES-62 highlights new interventional approaches in rheumatoid arthritis.Clinical and experimental immunology · 2014Review
- Article
- The helminth product, ES-62, protects against airway inflammation by resetting the Th cell phenotype.International journal for parasitology · 2013Article
- The therapeutic potential of the filarial nematode-derived immunodulator, ES-62 in inflammatory disease.Clinical and experimental immunology · 2010Article
- Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo.Immunology · 2008Article
- Signalling mechanisms underlying subversion of the immune response by the filarial nematode secreted product ES-62.Immunology · 2005Review
- Article
- Review
- Both free-living and parasitic nematodes induce a characteristic Th2 response that is dependent on the presence of intact glycans.Infection and immunity · 2004Article
- Hyporesponsiveness of murine B lymphocytes exposed to the filarial nematode secreted product ES-62 in vivo.Immunology · 2003Article
- Structural elucidation of zwitterionic carbohydrates derived from glycosphingolipids of the porcine parasitic nematode Ascaris suum.The Biochemical journal · 2003Article
- Modulation of a heterologous immune response by the products of Ascaris suum.Infection and immunity · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
Abstract
The filarial nematode product ES-62 contains phosphorylcholine (PC) covalently attached to N-linked glycans. ES-62 induced high levels of immunoglobulin G1 (IgG1) antibodies, but no IgG2a, to non-PC epitopes of the molecule following subcutaneous injection into BALB/c mice. Conversely, mice given ES-62 lacking PC demonstrated significant production of both IgG subclasses. Thus, PC appears to block production of IgG2a antibodies to other epitopes on the parasite molecule. A role for interleukin-10 (IL-10) in this effect was shown by the ability of IL-10(-/-) mice to make an IgG2a antibody response to non-PC epitopes of ES-62.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.