ArticleInfection and immunity2000
Maternal Trypanosoma cruzi infection upregulates capacity of uninfected neonate cells To produce pro- and anti-inflammatory cytokines.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
31 citing papers in PubMed, 1 synthesis or guideline pooled it, 72 citations in OpenAlex.
- SBC Guideline on the Diagnosis and Treatment of Patients with Cardiomyopathy of Chagas Disease - 2023.Arquivos brasileiros de cardiologia · 2023Guideline
- Trypanosoma cruzi infection in pregnancy: New approaches to address the diagnosis and follow-up of women and newborns.PLoS neglected tropical diseases · 2026Review
- Placental immunopathology and congenital transmission of Zika virus andFrontiers in immunology · 2026Review
- Trypanosoma cruzi Infection in Pregnancies without Congenital Transmission Is Associated with Reduced Fetal Growth: A Cross-Sectional Study in Argentina, Honduras, and Mexico.The American journal of tropical medicine and hygiene · 2024Article
- Parasitic Effects on the Congenital Transmission ofMicroorganisms · 2024Article
- Subunit nanovaccine elicited T cell functional activation controls Trypanosoma cruzi mediated maternal and placental tissue damage and improves pregnancy outcomes in mice.NPJ vaccines · 2023Article
- Monocytes from Uninfected Neonates Born toPathogens (Basel, Switzerland) · 2023Article
- Article
- The transcriptome landscape of 3D-cultured placental trophoblasts reveals activation of TLR2 and TLR3/7 in response to lowFrontiers in microbiology · 2023Article
- Macrophage-infectivity potentiator ofFrontiers in immunology · 2023Article
- Epigenetic signature of exposure to maternalEpigenomics · 2022Article
- Emerging and reemerging forms of Trypanosoma cruzi transmission.Memorias do Instituto Oswaldo Cruz · 2022Review
- Is Antibody-Dependent Enhancement ofFrontiers in immunology · 2021Article
- Chronic testicular Chlamydia muridarum infection impairs mouse fertility and offspring development†.Biology of reproduction · 2020Article
- Review
- Congenital Transmission ofFrontiers in microbiology · 2019Review
- Benznidazole affects expression of Th1, Th17 and Treg cytokines during acute experimentalThe journal of venomous animals and toxins including tropical diseases · 2017Article
- Between a bug and a hard place: Trypanosoma cruzi genetic diversity and the clinical outcomes of Chagas disease.Expert review of anti-infective therapy · 2015Review
- Congenital Chagas disease: an update.Memorias do Instituto Oswaldo Cruz · 2015Review
- Infants' Peripheral Blood Lymphocyte Composition Reflects Both Maternal and Post-Natal Infection with Plasmodium falciparum.PloS one · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The possibility of maternal in utero modulation of the innate and/or adaptive immune responses of uninfected newborns from Trypanosoma cruzi-infected mothers was investigated by studying the capacity of their whole blood cells to produce cytokines in response to T. cruzi lysate or lipopolysaccharide-plus-phytohemagglutinin (LPS-PHA) stimulation. Cells of such newborns occasionally released gamma interferon (IFN-gamma) and no interleukin-2 (IL-2) and IL-4 upon specific stimulation, while their mothers responded by the production of IFN-gamma, IL-2, and IL-4. Infection in mothers was also associated with a hyperactivation of maternal cells and also, strikingly, of cells of their uninfected neonates, since their release of proinflammatory (IL-1beta, IL-6, and tumor necrosis factor alpha [TNF-alpha]) as well as of anti-inflammatory (IL-10 and soluble TNF receptor) cytokines or factors was upregulated in the presence of LPS-PHA and/or parasite lysate. These results show that T. cruzi infection in mothers induces profound perturbations in the cytokine response of their uninfected neonates. Such maternal influence on neonatal innate immunity might contribute to limit the occurrence and severity of congenital infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.