ArticleInfection and immunity2000
Chronic Helicobacter pylori infection induces an apoptosis-resistant phenotype associated with decreased expression of p27(kip1).
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 69 citations in OpenAlex.
- A Genetic and Immunohistochemical Analysis of Helicobacter pylori Phenotypes and p27 Expression in Adenocarcinoma Patients in Jordan.Journal of epidemiology and global health · 2023Article
- Case Report: Morphologic and Functional Characteristics of Intestinal Mucosa in a Child With Short Bowel Syndrome After Treatment With Teduglutide: Evidence in Favor of GLP-2 Analog Safety.Frontiers in nutrition · 2022Article
- Interface-Based Structural Prediction of Novel Host-Pathogen Interactions.Methods in molecular biology (Clifton, N.J.) · 2019Article
- Structural host-microbiota interaction networks.PLoS computational biology · 2017Review
- Article
- Recapitulating Human Gastric Cancer Pathogenesis: Experimental Models of Gastric Cancer.Advances in experimental medicine and biology · 2016Review
- Phylogeographic origin of Helicobacter pylori determines host-adaptive responses upon coculture with gastric epithelial cells.Infection and immunity · 2013Article
- Helicobacter pylori decreases p27 expression through the delta opioid receptor-mediated inhibition of histone acetylation within the p27 promoter.Cancer letters · 2012Article
- Promotion of cytoplasmic mislocalization of p27 by Helicobacter pylori in gastric cancer.Oncogene · 2012Article
- The Role of PPARγ in Helicobacter pylori Infection and Gastric Carcinogenesis.PPAR research · 2012Article
- Rodent models of Helicobacter infection, inflammation, and disease.Methods in molecular biology (Clifton, N.J.) · 2012Review
- Helicobacter pylori interferes with an embryonic stem cell micro RNA cluster to block cell cycle progression.Silence · 2011Article
- Helicobacter pylori in the pathogenesis of gastric cancer and gastric lymphoma.Cancer letters · 2011Review
- Epidermal growth factor receptor activation protects gastric epithelial cells from Helicobacter pylori-induced apoptosis.Gastroenterology · 2009Article
- Article
- Gingipain-dependent interactions with the host are important for survival of Porphyromonas gingivalis.Frontiers in bioscience : a journal and virtual library · 2008Review
- Major histocompatibility complex class II inhibits fas antigen-mediated gastric mucosal cell apoptosis through actin-dependent inhibition of receptor aggregation.Infection and immunity · 2005Article
- p27kip1 expression is inversely related to the grade of gastric MALT lymphoma.International journal of gastrointestinal cancer · 2005Article
- Eradication of Helicobacter pylori induces apoptosis and inhibits proliferation of heterotopic proliferative glands in infected Mongolian gerbils.Cancer science · 2004Article
- Activation of the phosphatidylinositol 3-kinase/Akt pathway contributes to survival of primary epithelial cells infected with the periodontal pathogen Porphyromonas gingivalis.Infection and immunity · 2004Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 2 countries.
Funding
Abstract
Helicobacter pylori infection is associated with the development of gastric cancer. In short-term coculture with AGS gastric cells, H. pylori inhibits cell cycle progression and induces dose-dependent apoptosis. Based on the concept that an imbalance between proliferation and apoptosis may contribute to the emergence of gastric cancer, we chronically exposed AGS cells to H. pylori as a model of chronic exposure in humans. The AGS derivatives selected by this process were stably resistant not only to H. pylori-induced apoptosis but also to apoptosis induced by other enteric bacteria and by several toxic agents including radiation and cancer chemotherapy. Like the parental AGS cells, the derivatives underwent G(1)/S-phase cell cycle inhibition in response to H. pylori. The AGS derivatives displayed a marked decrease in cellular levels of the cell cycle control protein p27(kip1). We found a similar decrease in epithelial cell p27(kip1) expression in gastric biopsy specimens from H. pylori-infected patients. These findings are consistent with observations that link decreases in the p27(kip1) level to increased susceptibility to cancer in mice with p27(kip1) deleted and to a poor prognosis of gastric cancer in humans. This is the first demonstration that bacterial infection can lead to apoptosis resistance and to cross-resistance to other inducers of apoptosis such as bacteria, chemotherapeutic agents, and radiation. The development of apoptosis resistance and downmodulation of p27(kip1) may contribute to the increased risk for gastric cancer observed in humans chronically exposed to H. pylori.
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Registered trials
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