ArticleInfection and immunity2000
Interleukin 18 restores defective Th1 immunity to Candida albicans in caspase 1-deficient mice.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
35 citing papers in PubMed, 82 citations in OpenAlex.
- Cytosolic receptors and signaling in antifungal immunity.The EMBO journal · 2025Review
- IL-18 production is required for the generation of a Th1 response during experimental chromoblastomycosis.PloS one · 2025Article
- Pyroptosis in development, inflammation and disease.Frontiers in immunology · 2022Review
- Article
- Review
- Aim2 and Nlrp3 Are Dispensable for Vaccine-Induced Immunity against Francisella tularensis Live Vaccine Strain.Infection and immunity · 2021Article
- Role for IL-1 Family Cytokines in Fungal Infections.Frontiers in microbiology · 2021Review
- How Inflammasomes Inform Adaptive Immunity.Journal of molecular biology · 2018Review
- Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases.Immunological reviews · 2017Review
- Specific pathways mediating inflammasome activation by Candida parapsilosis.Scientific reports · 2017Article
- Integrating Inflammasome Signaling in Sexually Transmitted Infections.Trends in immunology · 2016Review
- Immune defence against Candida fungal infections.Nature reviews. Immunology · 2015Review
- Beyond canonical inflammasomes: emerging pathways in IL-1-mediated autoinflammatory disease.Seminars in immunopathology · 2014Review
- Syk signaling in dendritic cells orchestrates innate resistance to systemic fungal infection.PLoS pathogens · 2014Article
- Licensing Adaptive Immunity by NOD-Like Receptors.Frontiers in immunology · 2013Review
- IL-1β processing in mechanical ventilation-induced inflammation is dependent on neutrophil factors rather than caspase-1.Intensive care medicine experimental · 2013Article
- The CARD8 p.C10X mutation associates with a low anti-glycans antibody response in patients with Crohn's disease.BMC medical genetics · 2013Article
- Interplay between Candida albicans and the mammalian innate host defense.Infection and immunity · 2012Review
- The impact of caspase-12 on susceptibility to candidemia.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2012Article
- Dectin-1 is an extracellular pathogen sensor for the induction and processing of IL-1β via a noncanonical caspase-8 inflammasome.Nature immunology · 2012Article
Corrections and comments
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Authors and funding
9 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Caspase 1, formerly designated interleukin 1beta (IL-1beta)-converting enzyme, processes pro-IL-1beta and pro-IL-18 to yield active cytokines that play a pivotal role in inflammation and cell activation. We show here the effect of caspase 1 deficiency on the inflammatory and adaptive immune responses to the fungus Candida albicans. Caspase 1 deficiency did not affect susceptibility to primary systemic infection with the fungus, as revealed by survival and fungal growth. However, Th1-mediated resistance to reinfection was greatly impaired in caspase 1-deficient mice, and this correlated with low-level production of IL-12 and gamma interferon. Early in infection, production of these cytokines and that of tumor necrosis factor alpha, IL-6, and, interestingly, IL-1beta occurred normally in caspase 1-deficient mice, while that of IL-18 was severely impaired. Exogenous administration of IL-18, more than IL-12, restored the Th1-mediated resistance to the infection. We conclude that, while caspase 1 is not indispensable for release of mature IL-1beta in candidiasis, the caspase 1-dependent production of IL-18 may represent an important and novel pathway for the expression of sustained Th1 reactivity to the fungus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.