ArticleInfection and immunity2000
Invasion genes are not required for Salmonella enterica serovar typhimurium to breach the intestinal epithelium: evidence that salmonella pathogenicity island 1 has alternative functions during infection.
Article in Infection and immunity, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 93 citations in OpenAlex.
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- Dietary Acrylamide Intake Alters Gut Microbiota in Mice and Increases Its Susceptibility toFoods (Basel, Switzerland) · 2021Article
- A large panel of chicken cells are invadedOpen biology · 2021Article
- A three-dimensional intestinal tissue model reveals factors and small regulatory RNAs important for colonization with Campylobacter jejuni.PLoS pathogens · 2020Article
- Inhibition of the type III secretion system by syringaldehyde protects mice from Salmonella enterica serovar Typhimurium.Journal of cellular and molecular medicine · 2019Article
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- Supplemental invasion of Salmonella from the perspective of Salmonella enterica serovars Kentucky and Typhimurium.BMC microbiology · 2017Article
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- Salmonella Typhimurium strain ATCC14028 requires H2-hydrogenases for growth in the gut, but not at systemic sites.PloS one · 2014Article
- Salmonella pathogenicity and host adaptation in chicken-associated serovars.Microbiology and molecular biology reviews : MMBR · 2013Review
- Vaccination of chickens with SPI1-lon and SPI1-lon-fliC mutant of Salmonella enterica Serovar Enteritidis.PloS one · 2013Article
- Multiplicity of Salmonella entry mechanisms, a new paradigm for Salmonella pathogenesis.MicrobiologyOpen · 2012Article
- Mechanisms used by virulent Salmonella to impair dendritic cell function and evade adaptive immunity.Immunology · 2012Review
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- The bacterial cytoskeleton modulates motility, type 3 secretion, and colonization in Salmonella.PLoS pathogens · 2012Article
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Authors and funding
2 authors at 1 institution in 1 country.
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Abstract
Salmonella enterica serovar Typhimurium invasion genes are necessary for bacterial invasion of intestinal epithelial cells and are thought to allow salmonellae to enter and cross the intestinal epithelium during infection. Many invasion genes are encoded on Salmonella pathogenicity island 1 (SPI1), and their expression is activated by HilA, a transcription factor also encoded on SPI1. We have studied the role of Salmonella invasion genes during infection of mice following intragastric inoculation. We have found that strains containing a mutation in hilA or invG were recovered from the intestinal contents, intestinal tissues, and systemic tissues at a lower frequency than their parental wild-type strain. In contrast, a strain in which SPI1 is deleted was recovered from infected mice at a frequency similar to that of its parental wild-type strain. The DeltaSPI1 phenotype indicates that S. enterica does not require invasion genes to cross the intestinal epithelium and infect systemic tissues. This result has forced us to reconsider the long-held belief that invasion genes directly mediate bacterial infection of the intestinal mucosa and traversion of the intestinal barrier during infection. Instead, our results suggest that hilA is required for bacterial colonization of the host intestine. The seemingly contradictory phenotype of the DeltaSPI1 mutant suggests that deletion of another gene(s) encoded on SPI1 suppresses the hilA mutant defect. We propose a model for S. enterica pathogenesis in which hilA and invasion genes are required for salmonellae to overcome a host clearance response elicited by another SPI1 gene product(s).
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.