ReviewSpringer seminars in immunopathology1999
Alterations in the regulation of expression of the alpha 1(I) collagen gene (COL1A1) in systemic sclerosis (scleroderma).
Review in Springer seminars in immunopathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 34 citations in OpenAlex.
- Reviewing the Regulators of COL1A1.International journal of molecular sciences · 2023Review
- Transcriptome from opaque cornea of Fanconi anemia patient uncovers fibrosis and two connected players.Molecular genetics and metabolism reports · 2021Article
- Identification of Potential ceRNA Network and Patterns of Immune Cell Infiltration in Systemic Sclerosis-Associated Interstitial Lung Disease.Frontiers in cell and developmental biology · 2021Article
- Downregulation of CFIm25 amplifies dermal fibrosis through alternative polyadenylation.The Journal of experimental medicine · 2020Article
- LncRNA XIST promotes extracellular matrix synthesis, proliferation and migration by targeting miR-29b-3p/COL1A1 in human skin fibroblasts after thermal injury.Biological research · 2019Article
- Role of cultured skin fibroblasts in aesthetic and plastic surgery.World journal of plastic surgery · 2013Article
- Vascular involvement in systemic sclerosis (scleroderma).Journal of inflammation research · 2011Article
- Persistent activation of dermal fibroblasts from patients with gadolinium-associated nephrogenic systemic fibrosis.Annals of the rheumatic diseases · 2010Article
- Proteomic analysis identification of a pattern of shared alterations in the secretome of dermal fibroblasts from systemic sclerosis and nephrogenic systemic fibrosis.The American journal of pathology · 2010Article
- Transcription factor Fli1 regulates collagen fibrillogenesis in mouse skin.Molecular and cellular biology · 2009Article
- Adult xanthogranulomatous disease of the orbit and ocular adnexa: new immunohistochemical findings and clinical review.The British journal of ophthalmology · 2006Review
- Inhibition of collagen gene expression in systemic sclerosis dermal fibroblasts by mithramycin.Annals of the rheumatic diseases · 2005Article
- B-Myb acts as a repressor of human COL1A1 collagen gene expression by interacting with Sp1 and CBF factors in scleroderma fibroblasts.The Biochemical journal · 2004Article
- Persistent down-regulation of Fli1, a suppressor of collagen transcription, in fibrotic scleroderma skin.The American journal of pathology · 2003Article
- Control of connective tissue gene expression by TGF beta: role of Smad proteins in fibrosis.Current rheumatology reports · 2002Review
- Elevated expression of isopeptide bond cross-links contributes to fibrosis in scleroderma and the healing wounds of tight skin mice.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At present, the mechanisms that regulate the expression of collagen genes in normal and pathologic fibroblasts are not known. Thus, the detailed study of transcriptional regulation of COL1A1 in SSc cells will increase our current understanding of the pathophysiology of fibrotic diseases. These studies will yield valuable information regarding the important biological process of regulation of collagen gene expression under normal and pathologic conditions, a process that has remained elusive despite intense recent investigations. It is now evident that persistent overproduction of collagen is responsible for the progressive nature of tissue fibrosis in SSc. Up-regulation of collagen gene expression in SSc fibroblasts appears to be a critical event in this process. The coordinate transcriptional activation of numerous collagen genes suggests a fundamental alteration in the regulatory control of gene expression in SSc fibroblasts. Trans-acting nuclear factors which bind to cis-acting elements in enhancer (intronic) and promoter regions of the genes modulate the basal and inducible transcriptional activity of the collagen genes. The identification of the nuclear transcription factors that regulate normal collagen gene expression may provide promising approaches to the therapy of this incurable disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.