ReviewSpringer seminars in immunopathology1999
Fibroblast heterogeneity in physiological conditions and fibrotic disease.
Review in Springer seminars in immunopathology, 1999. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed.
- Transcriptomics ofMicroorganisms · 2024Article
- Identification of Periostin as a critical niche for myofibroblast dynamics and fibrosis during tendon healing.Matrix biology : journal of the International Society for Matrix Biology · 2024Article
- Ocular mucous membrane pemphigoid: a review.Immunologic research · 2019Review
- Tristetraprolin (TTP) coordinately regulates primary and secondary cellular responses to proinflammatory stimuli.Journal of leukocyte biology · 2015Article
- NGF Modulates trkANGFR/p75NTR in αSMA-Expressing Conjunctival Fibroblasts from Human Ocular Cicatricial Pemphigoid (OCP).PloS one · 2015Article
- Molecular and cellular basis of scleroderma.Journal of molecular medicine (Berlin, Germany) · 2014Review
- Mesenchymal stroma: primary determinant and therapeutic target for epithelial cancer.Trends in cell biology · 2013Review
- MicroRNAs in pulmonary arterial remodeling.Cellular and molecular life sciences : CMLS · 2013Review
- Transcription factor networks in invasion-promoting breast carcinoma-associated fibroblasts.Cancer microenvironment : official journal of the International Cancer Microenvironment Society · 2013Article
- The adventitia: essential regulator of vascular wall structure and function.Annual review of physiology · 2013Review
- Mannose receptor 2 attenuates renal fibrosis.Journal of the American Society of Nephrology : JASN · 2012Article
- Differential expression of matrix metalloproteases in human fibroblasts with different origins.Biochemistry research international · 2012Article
- Biological effects of extracorporeal shock waves on fibroblasts. A review.Muscles, ligaments and tendons journal · 2011Article
- Thymosin beta 4 prevents oxidative stress by targeting antioxidant and anti-apoptotic genes in cardiac fibroblasts.PloS one · 2011Article
- Article
- Cellular Interplay between Cardiomyocytes and Nonmyocytes in Cardiac Remodeling.International journal of inflammation · 2011Article
- The adventitia: Essential role in pulmonary vascular remodeling.Comprehensive Physiology · 2011Review
- The origin of fibroblasts and mechanism of cardiac fibrosis.Journal of cellular physiology · 2010Review
- Gene targeting to the stroma of the prostate and bone.Differentiation; research in biological diversity · 2008Review
- Adult xanthogranulomatous disease of the orbit and ocular adnexa: new immunohistochemical findings and clinical review.The British journal of ophthalmology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
Abstract
Inflammation and tissue injury are strong stimuli for fibroblast activation and initiation of reparative processes. In certain disease states, pathological fibrosis occurs. Fibroblasts isolated from these diseased tissues often display a persistently abnormal phenotype characterized by increased synthesis of matrix components such as collagen. This metabolic abnormality is apparently independent of continued exposure to any pathological stimulus that may have initiated the process. Since fibroblasts are heterogeneous in proliferative capacity, in synthesis of collagen and other matrix proteins and in response to immune mediators and growth factors, clonal selection, i.e. selective increase in fibroblast subpopulations, may explain the long-term effects of acute in vivo activation on fibroblast behavior. Studies of SSc fibroblasts are consistent with clonal selection and/or clonal activation, processes that may play an important role in fibrosis in this and other disorders.
Indexed as
Identifiers
10945032What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.