ArticleBritish journal of cancer2000
The association between atypical adenomatous hyperplasia and primary lung cancer.
Article in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
24 citing papers in PubMed, 134 citations in OpenAlex.
- Article
- Updates in grading and invasion assessment in lung adenocarcinoma.Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2022Review
- Article
- ARL4C is associated with initiation and progression of lung adenocarcinoma and represents a therapeutic target.Cancer science · 2020Article
- Rationale for Lung Adenocarcinoma Prevention and Drug Development Based on Molecular Biology During Carcinogenesis.OncoTargets and therapy · 2020Review
- Article
- Clinicopathological Characteristics and Mutations Driving Development of Early Lung Adenocarcinoma: Tumor Initiation and Progression.International journal of molecular sciences · 2018Review
- [Solitary AAH Arising from Extralobar Sequestration in A Less Than 3-year-old Boy: A Case Report].Zhongguo fei ai za zhi = Chinese journal of lung cancer · 2017Article
- Solitary Atypical Adenomatous Hyperplasia in a 12-Year-Old Girl.The Korean journal of thoracic and cardiovascular surgery · 2016Article
- Targeted sequencing reveals clonal genetic changes in the progression of early lung neoplasms and paired circulating DNA.Nature communications · 2015Article
- Prognostic significance of promoter CpG island hypermethylation and repetitive DNA hypomethylation in stage I lung adenocarcinoma.Virchows Archiv : an international journal of pathology · 2015Article
- Long-term effects of inhaled budesonide on screening-detected lung nodules.Annals of oncology : official journal of the European Society for Medical Oncology · 2015Article
- Chemoprevention studies within lung cancer screening programmes.Ecancermedicalscience · 2015Review
- C4.4A as a biomarker in pulmonary adenocarcinoma and squamous cell carcinoma.World journal of clinical oncology · 2014Review
- Fibroblast phenotypes in different lung diseases.Journal of cardiothoracic surgery · 2014Article
- A Case of Atypical Adenomatous Hyperplasia of Larger Than 2 cm.Tuberculosis and respiratory diseases · 2013Article
- Pulmonary adenocarcinoma: a renewed entity in 2011.Respirology (Carlton, Vic.) · 2012Review
- Do all lung adenocarcinomas follow a stepwise progression?Lung cancer (Amsterdam, Netherlands) · 2011Review
- DNA methylation changes in atypical adenomatous hyperplasia, adenocarcinoma in situ, and lung adenocarcinoma.PloS one · 2011Article
- Synchronous pulmonary atypical adenomatous hyperplasia and metastatic osteosarcoma in a young female.The Japanese journal of thoracic and cardiovascular surgery : official publication of the Japanese Association for Thoracic Surgery = Nihon Kyobu Geka Gakkai zasshi · 2004Article
Corrections and comments
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Atypical adenomatous hyperplasia (AAH) has been suggested as the adenoma in an adenoma-carcinoma sequence in the lung periphery. From 1989-1998, we undertook a systematic, prospective search for AAH in lungs resected for cancer. AAH was found in 67 of 554 patients (12. 1%) with primary lung carcinoma (9.2% in male patients and 19.0% in females). AAH was found in lungs bearing adenocarcinoma (23.2%) more frequently than with large cell undifferentiated carcinoma (12.5%) or squamous carcinoma (3.3%). A greater percentage of females with adenocarcinoma had AAH (30.2%) than did males with adenocarcinoma (18.8%). Numbers of AAH ranged from 1-42 per patient and more patients had small numbers of AAH, although 12 patients had 6 or more AAH foci. Larger numbers of AAH tended to be found in adenocarcinoma-bearing lungs. Ten of the 67 patients with AAH and primary lung carcinoma (15%) had multiple primary cancers (range 2-6), all of which were adenocarcinoma. Synchronous cancers were rare in lung tumour-bearing resections without AAH. Patients with AAH show no difference in post-operative survival to those without, for all stages of carcinoma and for Stage I disease alone. This study provides evidence for a strong association between atypical adenomatous hyperplasia and primary lung adenocarcinoma and lends weight to the AAH/adenoma-carcinoma hypothesis.
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