SynthesisBritish journal of cancer2000
A systematic review of the role of human papilloma virus (HPV) testing within a cervical screening programme: summary and conclusions.
Synthesis in British journal of cancer, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed.
- Assessing 10-Year Safety of a Single Negative HPV Test for Cervical Cancer Screening: Evidence from FOCAL-DECADE Cohort.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2021Trial
- Evidence of Decreased Long-term Risk of Cervical Precancer after Negative Primary HPV Screens Compared with Negative Cytology Screens in a Longitudinal Cohort Study.Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 2024Article
- Human papillomavirus anogenital screening in solid organ transplant recipients: a narrative review.Archives of gynecology and obstetrics · 2023Review
- Usefulness of the human papillomavirus DNA chip test as a complementary method for cervical cytology.CytoJournal · 2023Article
- Revisiting time to translation: implementation of evidence-based practices (EBPs) in cancer control.Cancer causes & control : CCC · 2021Article
- Article
- High lifetime probability of screen-detected cervical abnormalities.Journal of medical screening · 2017Article
- High risk HPV testing following treatment for cervical intraepithelial neoplasia.Irish journal of medical science · 2016Article
- Article
- A novel bifunctional hybrid with marine bacterium alkaline phosphatase and Far Eastern holothurian mannan-binding lectin activities.PloS one · 2014Article
- Factors associated with cervical cancer screening uptake among Inuit women in Nunavik, Quebec, Canada.BMC public health · 2013Article
- Prevalence of human papillomavirus in university young women.Oncology letters · 2011Article
- [Prevention of cervical cancer].Atencion primaria · 2005Article
- comparison of two commercial assays for detection of human papillomavirus (HPV) in cervical scrape specimens: validation of the Roche AMPLICOR HPV test as a means to screen for HPV genotypes associated with a higher risk of cervical disorders.Journal of clinical microbiology · 2005Article
- Attitudes towards HPV testing: a qualitative study of beliefs among Indian, Pakistani, African-Caribbean and white British women in the UK.British journal of cancer · 2003Article
- The causal relation between human papillomavirus and cervical cancer.Journal of clinical pathology · 2002Review
- What we could do now: molecular pathology of gynaecological cancer.Molecular pathology : MP · 2001Review
- Human papillomavirus testing in primary screening for the detection of high-grade cervical lesions: a study of 7932 women.British journal of cancer · 2001Article
- High-riskJournal of cytologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A systematic review of the available evidence on the role of HPV testing in cervical screening has been published by the Health Technology Assessment Committee of the UK Department of Health. The review summarized relevant data on testing methods, natural history, and prevalence of the virus in different disease groups. Cost-effectiveness modelling was undertaken. Ten major conclusions were reached and are reported here. The key conclusions were that HPV testing was more sensitive than cytology, but that there were concerns about specificity, especially in young women. The increased sensitivity led to a recommendation that HPV testing be introduced on a pilot basis for women with borderline and mild smears. HPV testing has great potential as a primary screening test, but large trials are needed to properly evaluate this application and to determine if its introduction can reduce invasive cancer rates. There is an urgent need to undertake a large trial of HPV testing in conjunction with other new technologies (liquid-based cytology and computer-assisted cytology reading) to determine the best way to integrate them into ongoing screening programmes. A range of issues including the age to start and stop screening, the appropriate screening interval, the role of self-sampling for HPV testing and the choice of primary test (HPV and/or cytology) require further evaluation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.