ArticleProceedings of the National Academy of Sciences of the United States of America2000
Multiple functional defects in peripheral autonomic organs in mice lacking muscarinic acetylcholine receptor gene for the M3 subtype.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2000. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 124 papers, 1 of them a synthesis that pooled it.
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Who cites it
124 citing papers in PubMed, 1 synthesis or guideline pooled it, 448 citations in OpenAlex.
- Beyond anti-SSA and anti-SSB. The clinical significance of new antibodies in the diagnosis of Sjögren disease.Rheumatology international · 2026Pooled it
- Memantine-Induced Sialorrhea: A Rare Adverse Reaction and Review of Pathophysiological Mechanisms.Cureus · 2026Article
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- Selective modulation of murine intestinal MAmerican journal of physiology. Cell physiology · 2026Article
- The role of acetylcholine and its receptors in tumor immune regulation: mechanisms and potential therapeutic targets.Molecular cancer · 2025Review
- Muscarinic acetylcholine receptor 3 localized to primary endothelial cilia regulates blood pressure and cognition.Scientific reports · 2025Article
- Experimental induction of anti-muscarinic type-3-receptor extracellular loop antibodies by immunization with 4-hydroxy-2-nonenal modified Ro60 and unmodified Ro60.Clinical and experimental immunology · 2025Article
- Effect of donepezil on bone metabolism among older adults with Alzheimer's disease.Contemporary clinical trials · 2025Article
- A Brief Overview of Cholinergic and Phosphodiesterase-5 Inhibitors in Diabetic Bladder Dysfunction.International journal of molecular sciences · 2024Review
- Intracellular signaling pathways of muscarinic acetylcholine receptor-mediated detrusor muscle contractions.American journal of physiology. Renal physiology · 2023Article
- Structural and functional analysis of salivary intercalated duct cells reveals a secretory phenotype.The Journal of physiology · 2023Article
- Long-term functional regeneration of radiation-damaged salivary glands through delivery of a neurogenic hydrogel.Science advances · 2022Article
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- Sophisticated regulation of micturition: review of basic neurourology.Journal of exercise rehabilitation · 2021Review
- Highly localized intracellular CaeLife · 2021Article
- Muscarinic Acetylcholine Receptors in the Retina-Therapeutic Implications.International journal of molecular sciences · 2021Review
- Article
- Cell signaling regulation in salivary gland development.Cellular and molecular life sciences : CMLS · 2021Review
64 more citing papers are in PubMed but not listed here.
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8 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Muscarinic acetylcholine receptors consist of five distinct subtypes and have been important targets for drug development. In the periphery, muscarinic acetylcholine receptors mediate cholinergic signals to autonomic organs, but specific physiological functions of each subtype remain poorly elucidated. Here, we have constructed and analyzed mutant mice lacking the M(3) receptor and have demonstrated that this subtype plays key roles in salivary secretion, pupillary constriction, and bladder detrusor contractions. However, M(3)-mediated signals in digestive and reproductive organs are dispensable, likely because of redundant mechanisms through other muscarinic acetylcholine receptor subtypes or other mediators. In addition, we have found prominent urinary retention only in the male, which indicates a considerable sex difference in the micturition mechanism. Accordingly, this mutant mouse should provide a useful animal model for investigation of human diseases that are affected in the peripheral cholinergic functions.
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